Publication Name	World Journal of Gastroenterology
Manuscript ID	69467
Country	New Zealand

Received	2021-07-01 03:21
Peer-Review Started	2021-07-01 03:28
To Make the First Decision
Return for Revision	2021-07-13 23:48
Revised	2021-07-16 03:30
Second Decision	2021-09-17 03:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2021-09-19 08:46
Articles in Press	2021-09-19 08:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2021-10-25 01:31
Publish the Manuscript Online	2021-10-27 07:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Nutrition & Dietetics
Manuscript Type	Opinion Review
Article Title	Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption
Manuscript Source	Unsolicited Manuscript
All Author List	Ivana Roosevelt Sequeira
ORCID	Author(s) ORCID Number Ivana Roosevelt Sequeira http://orcid.org/0000-0001-5414-9925
Funding Agency and Grant Number
Corresponding Author	Ivana Roosevelt Sequeira, PhD, Research Fellow, Human Nutrition Unit, School of Biological Science, University of Auckland, 18 Carrick Place, Mount Eden, Auckland 1024, New Zealand. i.sequeira@auckland.ac.nz
Key Words	Aspirin; Ascorbic acid; Paracellular permeability; Antioxidant; Lactulose mannitol test
Core Tip	The significance of plasma ascorbic acid (AA) is underscored by its enzymatic and antioxidant properties as well as involvement in many aspects of health including the synthesis of biomolecules during acute illness, trauma and chronic health conditions. Dietary intake supports maintenance of optimal levels with supplementation at higher doses more likely pursued. Transient increased intestinal paracellular permeability following high dose AA may be utilised to enhance delivery of other micronutrients across the intestinal lumen. The potential mechanism following dietary intake however needs further study but may provide an avenue to increase small intestinal nutrient co transport and absorption, including in acute and chronic illness.
Publish Date	2021-10-27 07:14
Citation	Sequeira IR. Higher doses of ascorbic acid may have the potential to promote nutrient delivery via intestinal paracellular absorption. World J Gastroenterol 2021; 27(40): 6750-6756
URL	https://www.wjgnet.com/1007-9327/full/v27/i40/6750.htm
DOI	https://dx.doi.org/10.3748/wjg.v27.i40.6750

Full Article (PDF)	WJG-27-6750.pdf
Full Article (Word)	WJG-27-6750.docx
Manuscript File	69467_Auto_Edited.docx
Answering Reviewers	69467-Answering reviewers.pdf
Audio Core Tip	69467-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	69467-Conflict-of-interest statement.pdf
Copyright License Agreement	69467-Copyright license agreement.pdf
Peer-review Report	69467-Peer-review(s).pdf
Scientific Misconduct Check	69467-Bing-Wang JJ-2.png
Scientific Editor Work List	69467-Scientific editor work list.pdf