Publication Name	World Journal of Diabetes
Manuscript ID	71809
Country	Netherlands

Received	2021-09-23 13:19
Peer-Review Started	2021-09-23 13:21
To Make the First Decision
Return for Revision	2021-11-08 04:17
Revised	2021-12-24 22:23
Second Decision	2022-02-08 05:59
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-02-10 16:31
Articles in Press	2022-02-10 16:31
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-01-26 11:03
Typeset the Manuscript	2022-02-23 08:48
Publish the Manuscript Online	2022-03-15 14:23

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Letter to the Editor
Article Title	Free fatty acids, glucose, and insulin in type 2 diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Rob NM Weijers
ORCID	Author(s) ORCID Number Rob NM Weijers http://orcid.org/0000-0003-2315-6756
Funding Agency and Grant Number
Corresponding Author	Rob NM Weijers, PhD, Teacher, Teaching Hospital, OLVG, Oosterpark 9, 1091 AC Amsterdam 9, Amsterdam 95500, Netherlands. robw01@xs4all.nl
Key Words	Free fatty acids; Membrane flexibility; NKX2-1 gene; RNA sequencing; Type 2 diabetes; TPD52L-3 gene; Unsaturation index
Core Tip	A substantial reduction in both NKX2-1 and TPD52L3 proteins is largely responsible for a reduction in carbon-carbon double bonds of phospholipids which, in turn, translates into the redistribution of the lateral pressure profile, and thereby reduces the transport speed of glucose molecules across the cell membrane. Consequently, the amount of plasma glucose entering the β-cell via GLUT2 gives a false negative result. Also the redistribution of the lateral pressure profile lowers the insulin release from β-cells into the blood circulation. Both phenomena cause the onset of type 2 diabetes mellitus.
Publish Date	2022-03-15 14:23
Citation	Weijers RN. Free fatty acids, glucose, and insulin in type 2 diabetes mellitus. World J Diabetes 2022; 13(3): 275-277
URL	https://www.wjgnet.com/1948-9358/full/v13/i3/275.htm
DOI	https://dx.doi.org/10.4239/wjd.v13.i3.275

Full Article (PDF)	WJD-13-275.pdf
Full Article (Word)	WJD-13-275.docx
Manuscript File	71809_Auto_Edited.docx
Answering Reviewers	71809-Answering reviewers.pdf
Audio Core Tip	71809-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	71809-Conflict-of-interest statement.pdf
Copyright License Agreement	71809-Copyright license agreement.pdf
Peer-review Report	71809-Peer-review(s).pdf
Scientific Editor Work List	71809-Scientific editor work list.pdf