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Articles Published Processes
2/22/2022 9:25:38 AM | Browse: 258 | Download: 627
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Received |
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2021-11-20 19:35 |
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Peer-Review Started |
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2021-11-20 19:37 |
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To Make the First Decision |
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Return for Revision |
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2021-12-28 19:46 |
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Revised |
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2022-01-08 01:36 |
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Second Decision |
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2022-02-14 05:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2022-02-16 07:17 |
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Articles in Press |
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2022-02-16 07:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-02-17 07:03 |
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Publish the Manuscript Online |
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2022-02-22 09:25 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Sameh A Lashen, Mohammed M Shamseya, Marwa A Madkour, Radwa M Abdel Salam and Sanaa S Mostafa |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Sameh A Lashen, MD, PhD, Associate Professor, Internal Medicine (Hepatology and Gastroenterology division), Faculty of Medicine, Alexandria University, Champollion Street, El-Khartoum Square, Azarita Medical Campus, Alexandria 21521, Egypt. sameh.lashen@alexmed.edu.eg |
| Key Words |
β-arrestin-2; Portal hypertension; Variceal bleeding; Nonselective beta-blockers; Portal congestion index; Variceal ligation |
| Core Tip |
Gastric antral β-Arrestin-2 (β-Arr-2) expression correlates to portal hypertension in terms of esophageal varices and portal gastropathy. A stronger β-Arr-2 expression is associated with a sustained clinical response to nonselective β-blockers (NSBB) with a longer variceal bleeding-free interval. Patients who experienced variceal bleeding while on NSBB had lower baseline serum and tissue expression of β-Arr-2. In patients with responded to NSBB, the expression of β-Arr-2 was reduced after long-term treatment. The serum level of β-Arr-2 correlates to its antral expression and showed high sensitivity and specificity for defining the subgroup of patients who will respond to NSBB. |
| Publish Date |
2022-02-22 09:25 |
| Citation |
Lashen SA, Shamseya MM, Madkour MA, Abdel Salam RM, Mostafa SS. β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study. World J Hepatol 2022; 14(2): 429-441 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i2/429.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i2.429 |
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