Publication Name	World Journal of Gastroenterology
Manuscript ID	75137
Country	United States

Received	2022-01-16 20:49
Peer-Review Started	2022-01-16 20:50
To Make the First Decision
Return for Revision	2022-04-11 08:47
Revised	2022-04-22 15:21
Second Decision	2022-06-13 03:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-06-20 15:46
Articles in Press	2022-06-20 15:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-06-23 09:09
Publish the Manuscript Online	2022-07-18 09:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tumor microenvironment in pancreatic ductal adenocarcinoma: Implications in immunotherapy
Manuscript Source	Invited Manuscript
All Author List	Caitlyn Smith, Wei Zheng, Jixin Dong, Yaohong Wang, Jinping Lai, Xiuli Liu and Feng Yin
ORCID	Author(s) ORCID Number Caitlyn Smith http://orcid.org/0000-0001-8944-0480 Wei Zheng http://orcid.org/0000-0003-3193-2655 Jixin Dong http://orcid.org/0000-0002-2757-4464 Yaohong Wang http://orcid.org/0000-0001-5964-0465 Jinping Lai http://orcid.org/0000-0001-5365-2481 Xiuli Liu http://orcid.org/0000-0001-5791-2017 Feng Yin http://orcid.org/0000-0002-8444-1123
Funding Agency and Grant Number
Corresponding Author	Feng Yin, MD, PhD, Assistant Professor, Department of Pathology and Anatomical Sciences, University of Missouri, One Hospital Drive, MSB M263, Columbia, MO 65212, United States. fengyin@health.missouri.edu
Key Words	Pancreatic ductal adenocarcinoma; Tumor microenvironment; Immunotherapy; Clinical trial; Chemotherapy; Treatment
Core Tip	Despite advances in basic and translational research, pancreatic cancer remains one of the most lethal cancers. Recent breakthroughs in immunotherapy have revolutionized cancer therapy and have shown great potential to transform pancreatic cancer treatment. However, due to the barrier related to the tumor microenvironment, pancreatic cancer has shown inferior treatment outcomes toward various immunotherapy regimens. Further efforts, such as combinatory immunotherapy or molecular tumor subtyping, are warranted to overcome immunotherapy resistance in pancreatic cancer.
Publish Date	2022-07-18 09:47
Citation	Smith C, Zheng W, Dong J, Wang Y, Lai J, Liu X, Yin F. Tumor microenvironment in pancreatic ductal adenocarcinoma: Implications in immunotherapy. World J Gastroenterol 2022; 28(27): 3297-3313
URL	https://www.wjgnet.com/1007-9327/full/v28/i27/3297.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i27.3297

Full Article (PDF)	WJG-28-3297.pdf
Full Article (Word)	WJG-28-3297.docx
Manuscript File	75137_Auto_Edited_LM.docx
Answering Reviewers	75137-Answering reviewers.pdf
Audio Core Tip	75137-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	75137-Conflict-of-interest statement.pdf
Copyright License Agreement	75137-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	75137-Language certificate.pdf
Peer-review Report	75137-Peer-review(s).pdf
Scientific Editor Work List	75137-Scientific editor work list.pdf