| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Randomized Controlled Trial |
| Article Title |
Effect of probiotics on hemodynamic changes and complications associated with cirrhosis: A pilot randomized controlled trial
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Roman Maslennikov, Irina Efremova, Vladimir Ivashkin, Maria Zharkova, Elena Poluektova, Elena Shirokova and Konstantin Ivashkin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Biocodex Microbiota Foundation: National Research Grant Russia 2019 |
|
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| Corresponding Author |
Roman Maslennikov, MD, PhD, Assistant Professor, Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya str. 1, Moscow, 119435, Russian Federation., Moscow 119435, Russia. mmmm00@yandex.ru |
| Key Words |
Gut; Gut-liver axis; Microbiota; Hemodynamics; Heart; Gut-heart axis; Saccharomyces boulardii; Portal hypertension |
| Core Tip |
Bacterial translocation exacerbates the hyperdynamic circulation observed in cirrhosis and contributes to a more severe disease course. Probiotics may reduce bacterial translocation and may therefore be useful to redress the circulatory imbalance. The aim of the study was to investigate the effect of probiotics on hemodynamic parameters, systemic inflammation, and complications of cirrhosis in this randomized placebo-controlled trial. Following a 3-month course of probiotics, we observed amelioration of hyperdynamic circulation and systemic inflammation, improvement liver function, regression of ascites and hepatic encephalopathy, and an increase in serum sodium level. |
| Publish Date |
2022-08-26 09:51 |
| Citation |
Maslennikov R, Efremova I, Ivashkin V, Zharkova M, Poluektova E, Shirokova E, Ivashkin K. Effect of probiotics on hemodynamic changes and complications associated with cirrhosis: A pilot randomized controlled trial. World J Hepatol 2022;14(8): 1667-1677 |
| URL |
https://www.wjgnet.com/1948-5182/full/v14/i8/1667.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v14.i8.1667 |
