Publication Name	World Journal of Clinical Cases
Manuscript ID	76813
Country	China

Received	2022-04-01 12:37
Peer-Review Started	2022-04-01 12:40
To Make the First Decision
Return for Revision	2022-06-07 07:36
Revised	2022-06-16 13:26
Second Decision	2022-07-13 02:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-07-17 23:07
Articles in Press	2022-07-17 23:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-07-08 09:27
Typeset the Manuscript	2022-07-25 05:57
Publish the Manuscript Online	2022-08-16 01:35

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Opinion Review
Article Title	NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease?
Manuscript Source	Unsolicited Manuscript
All Author List	Mao-Lin Zhang, Longqing Ran, Mengjun Wu, Qinchen Jia, Zhiming Qin and Yong G. Peng
ORCID	Author(s) ORCID Number Mao-Lin Zhang http://orcid.org/0000-0003-3366-4156 Mengjun Wu http://orcid.org/0000-0002-6899-4318 Zhiming Qin http://orcid.org/0000-0002-7538-5596
Funding Agency and Grant Number
Corresponding Author	Zhiming Qin, MS, Assistant Professor, Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing, China, Chongqing 400042, China. qzm201596@163.com
Key Words	Gastroesophageal reflux disease; NF-κB; Pathogenesis; Mechanism; Inflammatory injury; Esophageal epithelial barrier
Core Tip	Gastroesophageal reflux disease (GERD) is one of the most common chronic diseases. Current treatments, including drugs and surgery, have significant side effects and some patients do not respond to treatment. This article reviews the pathogenesis of GERD, especially the relationship between the NF-κB pathway and GERD. We also assessed the latest studies on the effects of drugs inhibiting the NF-κB pathway in GERD, providing new possibilities for the treatment of GERD.
Publish Date	2022-08-16 01:35
Citation	Zhang ML, Ran LQ, Wu MJ, Jia QC, Qin ZM, Peng YG. NF-κB: A novel therapeutic pathway for gastroesophageal reflux disease? World J Clin Cases 2022; 10(24): 8436-8442
URL	https://www.wjgnet.com/2307-8960/full/v10/i24/8436.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i24.8436

Full Article (PDF)	WJCC-10-8436.pdf
Full Article (Word)	WJCC-10-8436.docx
Manuscript File	76813_Auto_Edited-YJM-Webster J-LS.docx
Answering Reviewers	76813-Answering reviewers .pdf
Audio Core Tip	76813-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	76813-Conflict-of-interest statement.pdf
Copyright License Agreement	76813-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	76813-Language certificate.pdf
Peer-review Report	76813-Peer-review(s).pdf
Scientific Misconduct Check	76813-Bing-Ma YJ-2.png
Scientific Editor Work List	76813-Scientific editor work list.pdf