Publication Name	World Journal of Diabetes
Manuscript ID	7949
Country	United States

Received	2013-12-08 11:52
Peer-Review Started	2013-12-08 15:08
To Make the First Decision	2014-02-27 10:04
Return for Revision	2014-03-04 20:49
Revised	2014-05-15 00:00
Second Decision	2014-06-03 16:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-03 16:28
Articles in Press	2014-06-03 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-08-05 18:37
Publish the Manuscript Online	2014-08-17 13:16

ISSN	1948-9358 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Counterregulation of insulin by leptin as key component of autonomic regulation of body weight
Manuscript Source	Invited Manuscript
All Author List	Katarina T Borer
Funding Agency and Grant Number
Corresponding Author	Katarina T Borer, PhD, Professor, School of Kinesiology, The University of Michigan, 401 Washtenaw Avenue, Ann Arbor, MI 48109, United States. katarina@umich.edu
Key Words	Insulin; Leptin; Weight regulation; Autonomic; Circadian
Core Tip	The novel proposal for the mechanism of body weight regulation deals with all three components of body mass: bone, lean tissue, and fat depots. It attributes the central control of counterbalancing energy expenditure and intake to an autonomic nervous system-circadian clock command center that encompases brain reward substrates, lateral hypothalamic peptidergic circuits and areas of the cortex. The nonhomeostatic character of feeding and locomotion is driven and controlled by the reward circuits and modulated by shifts in insulin sensitivity induced by counterregulation by leptin of insulin as weight deviates between underweight and overweight and alters basal leptin concentrations.
Publish Date	2014-08-17 13:16
Citation	Borer KT. Counterregulation of insulin by leptin as key component of autonomic regulation of body weight. World J Diabetes 2014; 5(5): 606-629
URL	http://www.wjgnet.com/1948-9358/full/v5/i5/606.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i5.606

Full Article (PDF)	WJD-5-606.pdf
Full Article (Word)	WJD-5-606.doc
Manuscript File	7949-Review.docx
Answering Reviewers	7949-Answering reviewers.pdf
Copyright License Agreement	7949-Copyright assignment.pdf
Peer-review Report	7949-Peer review(s).pdf
Scientific Misconduct Check	7949-CrossCheck.jpg
Scientific Editor Work List	7949-Scientific editor work list.pdf