| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zi-Li Ai, Xian Zhang, Wei Ge, You-Bao Zhong, Hai-Yan Wang, Zheng-Yun Zuo and Duan-Yong Liu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No.82060836 |
| Jiangxi Province Graduate Student Innovation Special Fund Project |
YC2021-B146 |
| Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program |
CXTD22008 |
|
| Corresponding Author |
Hai-Yan Wang, PhD, Associate Professor, Formula-Pattern Research Center, Jiangxi University of Chinese Medicine, No. 1688 Meiling Road, Nanchang 330004, Jiangxi Province, China. 378278287@qq.com |
| Key Words |
Salvia miltiorrhiza extract; Obesity; Gut microbiota; Lipid metabolism; High fat diet |
| Core Tip |
Obesity is a major public health issue today and an obesity-related change in gut microbiota composition and its metabolite profile has been demonstrated. As a commonly used traditional Chinese medicine, Salvia miltiorrhiza extract (Sal) has many pharmacological effects, including anticoagulant, anti-inflammation, antioxidation, anti-fibrosis, anti-tumor, and organ protection. Although it has not been documented, Sal has a regulatory effect on obesity, which may be related to the gut microbiota. In the present study, we found that Sal plays a role in weight loss, lowering serum lipid levels, regulating the gut microbiota, and improving intestinal fecal metabolites in obese rats. |
| Publish Date |
2022-11-16 11:26 |
| Citation |
Ai ZL, Zhang X, Ge W, Zhong YB, Wang HY, Zuo ZY, Liu DY. Salvia miltiorrhiza extract may exert an anti-obesity effect in rats with high-fat diet-induced obesity by modulating gut microbiome and lipid metabolism. World J Gastroenterol 2022; 28(43): 6131-6156 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i43/6131.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i43.6131 |
