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Articles Published Processes
3/15/2023 3:41:16 PM | Browse: 141 | Download: 269
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Received |
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2022-10-12 12:18 |
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Peer-Review Started |
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2022-10-12 12:22 |
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To Make the First Decision |
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Return for Revision |
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2022-11-06 02:01 |
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Revised |
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2022-11-26 17:12 |
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Second Decision |
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2023-02-24 03:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-02-28 00:40 |
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Articles in Press |
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2023-02-28 00:40 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-09 10:36 |
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Publish the Manuscript Online |
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2023-03-15 15:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Phiwayinkosi V Dludla, Sihle E Mabhida, Khanyisani Ziqubu, Bongani B Nkambule, Sithandiwe E Mazibuko-Mbeje, Sidney Hanser, Albert Kotze Basson, Carmen Pheiffer and Andre Pascal Kengne |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Biomedical Research and Innovation Platform, of the South African Medical Research Council (SAMRC), and the National Research Foundation |
132534, 141929 |
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| Corresponding Author |
Phiwayinkosi V Dludla, PhD, Adjunct Professor, Biomedical Research and Innovation Platform, South African Medical Research Council, Francie van Zijl Drive Parow valley, Cape Town; PO Box 19070 7505 Tygerberg, Cape Town 7505, South Africa. pdludla@mrc.ac.za |
| Key Words |
Type 2 diabetes; Insulin resistance; β-cell dysfunction; Inflammation; Oxidative stress |
| Core Tip |
Elevated markers of inflammation and oxidative stress are related to β-cell dysfunction, the intracellular defense (antioxidant) mechanisms responsible for ameliorating some of these effects are significantly depleted during type 2 diabetes (T2D). Thus, beyond lowering glucose levels like most antidiabetic drugs, future research should invest in developing therapeutic agents to ameliorate inflammation and oxidative stress to improve blood control in patients with T2D. |
| Publish Date |
2023-03-15 15:41 |
| Citation |
Dludla PV, Mabhida SE, Ziqubu K, Nkambule BB, Mazibuko-Mbeje SE, Hanser S, Basson AK, Pheiffer C, Kengne AP. Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress. World J Diabetes 2023; 14(3): 130-146 |
| URL |
https://www.wjgnet.com/1948-9358/full/v14/i3/130.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v14.i3.130 |
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