Publication Name	World Journal of Gastroenterology
Manuscript ID	8141
Country	China

Received	2013-12-18 10:09
Peer-Review Started	2013-12-18 17:23
To Make the First Decision	2014-02-14 15:25
Return for Revision	2014-02-18 09:28
Revised	2014-02-25 04:02
Second Decision	2014-03-19 13:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-19 14:01
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-04-02 09:49
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Evidence-Based Medicine
Article Title	Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Qing Yang, Yun-Fei Xu, Sen Guo, Yi Liu, Shang-Lei Ning, Xiao-Fei Lu, Hui Yang and Yu-Xin Chen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81172044
Corresponding Author	Yu-Xin Chen, Professor, Department of Hepatobiliary Surgery, Qilu Hospital of Shandong University, 44 Wenhuaxi Road, Jinan 250012, Shandong Province, China. cyxsdu2012@163.com
Key Words	Nerve growth factor; Tropomyosin-receptor-kinase; Prognosis; Intrahepatic cholangiocarcinoma; Progression
Core Tip	For the first time, we systemically investigated nerve growth factor (NGF) and tropomyosin-receptor-kinase (TrkA) expression in 83 intrahepatic cholangiocarcinoma(IHCC) samples by immunohistochemistry, and then analyzed the expression relationship with clinicopathological features, which resulted in finding that NGF and TrkA were significantly associated with differentiation (P = 0.024) and intraneural invasion (P = 0.003) respectively. Moreover, we found that NGF and TrkA double higher expression had poorer prognosis than others. NGF-TrkA double higher expression was further confirmed as an independent prognostic factor by multivariate analysis. With function assays we demonstrated that NGF-TrkA signaling pathway played a crucial role in cholangiocarcinoma proliferation and invasion, indicating NGF-TrkA pathway could be a promising potential drug target of intrahepatic cholangiocarcinoma.
Publish Date	2014-04-14 10:49
Citation	Yang XQ, Xu YF, Guo S, Liu Y, Ning SL, Lu XF, Yang H, Chen YX. Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma. World J Gastroenterol 2014; 20(14): 4076-4084
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/4076.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.4076

Full Article (PDF)	WJG-20-4076.pdf
Full Article (Word)	WJG-20-4076.doc
Manuscript File	8141-Review.docx
Answering Reviewers	8141-Answering reviewers.pdf
Copyright License Agreement	8141-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8141-Language certificate.pdf
Peer-review Report	8141-Peer review(s).pdf
Scientific Editor Work List	8141-Scientific editor work list.doc