| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prevalence of non-alcoholic fatty liver disease in patients with nephrotic syndrome: A population-based study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Somtochukwu Stephen Onwuzo, Asif Ali Hitawala, Antoine Boustany, Prabhat Kumar, Ashraf Almomani, Chidera Onwuzo, Jessy Mascarenhas Monteiro and Imad Asaad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Somtochukwu Stephen Onwuzo, MD, Doctor, Internal Medicine, Cleveland Clinic Foundation, 18101 Lorain Road, Cleveland, OH 44111, United States. onwuzos@ccf.org |
| Key Words |
Non-alcoholic fatty liver disease; Nephrotic syndrome; Chronic kidney disease; Hyperlipidemia; Population-based study; Database |
| Core Tip |
We conducted a population-based study to investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with Nephrotic syndrome. We screened over 78 million individuals in a nationwide multicenter database. We performed a comprehensive multivariate analysis accounting for multiple cofounding factors including age ≥ 65 years, gender, Caucasian race, obesity, diabetes mellitus type 2, metabolic syndrome, dyslipidemia, chronic kidney disease and hypothyroidism. We found that patients with nephrotic syndrome had a higher prevalence of NAFLD. However, we could not account for certain confounders such as elevated uric acid levels, hormonal therapy, chemotherapy for tumors, and certain drugs such as corticosteroids, which are known to be risk factors for NAFLD. Further studies are required to confirm these findings and assess the utility of surveillance strategies for NAFLD in patients with nephrotic syndrome. |
| Publish Date |
2023-02-24 13:35 |
| Citation |
Onwuzo SS, Hitawala AA, Boustany A, Kumar P, Almomani A, Onwuzo C, Monteiro JM, Asaad I. Prevalence of non-alcoholic fatty liver disease in patients with nephrotic syndrome: A population-based study. World J Hepatol 2023; 15(2): 265-273 |
| URL |
https://www.wjgnet.com/1948-5182/full/v15/i2/265.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v15.i2.265 |
