ISSN |
2220-3249 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Infectious Diseases |
Manuscript Type |
Basic Study |
Article Title |
Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma
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Manuscript Source |
Invited Manuscript |
All Author List |
Ryuta Kojima, Shingo Nakamoto, Tadayoshi Kogure, Yaojia Ma, Keita Ogawa, Terunao Iwanaga, Na Qiang, Junjie Ao, Ryo Nakagawa, Ryosuke Muroyama, Masato Nakamura, Tetsuhiro Chiba, Jun Kato and Naoya Kato |
ORCID |
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Funding Agency and Grant Number |
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Corresponding Author |
Shingo Nakamoto, MD, PhD, Assistant Professor, Department of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chuo-ku, Chiba 260-8670, Japan. nakamotoer@faculty.chiba-u.jp |
Key Words |
Carcinoma; Hepatocellular; Hepatitis B virus; Virus Integration |
Core Tip |
To understand the role of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC) development, we re-analyzed HBV integration sites using publicly available data. We found that chromosome 11q13.3 is a frequently observed HBV integration site. This region contains important cancer driver genes, such as CCND1 and FGF19, which are amplified in HCC. This finding supports a mechanism of carcinogenesis promoted by HBV-induced genomic instability in the liver and provides insights into treating a subset of liver cancers. |
Publish Date |
2023-06-21 09:17 |
Citation |
Kojima R, Nakamoto S, Kogure T, Ma Y, Ogawa K, Iwanaga T, Qiang N, Ao J, Nakagawa R, Muroyama R, Nakamura M, Chiba T, Kato J, Kato N. Re-analysis of hepatitis B virus integration sites reveals potential new loci associated with oncogenesis in hepatocellular carcinoma. World J Virol 2023; 12(3): 209-220 |
URL |
https://www.wjgnet.com/2220-3249/full/v12/i3/209.htm |
DOI |
https://dx.doi.org/10.5501/wjv.v12.i3.209 |