Publication Name	World Journal of Clinical Oncology
Manuscript ID	8263
Country	Italy

Received	2013-12-22 15:21
Peer-Review Started	2013-12-22 18:54
To Make the First Decision	2014-02-27 11:20
Return for Revision	2014-03-06 09:21
Revised	2014-04-24 19:32
Second Decision	2014-05-29 09:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:52
Articles in Press	2014-05-29 10:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-07-18 10:13
Publish the Manuscript Online	2014-08-01 15:17

ISSN	2218-4333 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Topic Highlights
Article Title	Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets
Manuscript Source	Invited Manuscript
All Author List	Nadia Rucci, Patrizia Sanità, Simona Delle Monache, Edoardo Alesse and Adriano Angelucci
Funding Agency and Grant Number
Corresponding Author	Adriano Angelucci, Professor, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Via Vetoio, Coppito 67100, L’Aquila, Italy. adriano.angelucci@univaq.it
Key Words	Breast cancer; Bone metastasis; Targeted therapy; Osteoclasts
Core Tip	Breast cancer cells preferentially colonize bone sites during their metastatic diffusion. Bone microenvironment and tumor cells operate a reciprocal selective pressure that results in the formation of osteolytic lesion and tumor progression. Targeting the molecular factors involved in this interaction has been demonstrated to be an effective strategy in preventing the clinical morbidity associated with bone metastases. In this review, we summarize physiopathologic aspects of bone metastases from breast cancer and discuss the most promising therapeutic targets for their future clinical management.
Publish Date	2014-08-01 15:17
Citation	Rucci N, Sanità P, Delle Monache S, Alesse E, Angelucci A. Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets. World J Clin Oncol 2014; 5(3): 335-347
URL	http://www.wjgnet.com/2218-4333/full/v5/i3/335.htm
DOI	http://dx.doi.org/10.5306/wjco.v5.i3.335

Full Article (PDF)	WJCO-5-335.pdf
Full Article (Word)	WJCO-5-335.doc
Manuscript File	8263-Review.docx
Answering Reviewers	8263-Answering reviewers.pdf
Copyright License Agreement	8263-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	8263-Language certificate.pdf
Peer-review Report	8263-Peer review(s).pdf
Scientific Misconduct Check	8263-CrossCheck.jpg
Scientific Editor Work List	8263-Scientific editor work list.pdf