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8/10/2023 1:26:04 PM | Browse: 91 | Download: 280
Publication Name World Journal of Gastroenterology
Manuscript ID 83782
Country China
Received
2023-02-09 03:31
Peer-Review Started
2023-02-09 03:35
To Make the First Decision
Return for Revision
2023-05-16 11:42
Revised
2023-05-26 10:36
Second Decision
2023-07-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2023-07-17 01:26
Articles in Press
2023-07-17 01:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2023-08-03 07:52
Publish the Manuscript Online
2023-08-10 13:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments
Manuscript Source Unsolicited Manuscript
All Author List Xi-Rui Fan, Yun Huang, Yu Su, Si-Jin Chen, Yu-Lu Zhang, Wei-Kang Huang and Hui Wang
ORCID
Author(s) ORCID Number
Xi-Rui Fan http://orcid.org/0000-0002-9111-7823
Wei-Kang Huang http://orcid.org/0000-0003-4825-8337
Hui Wang http://orcid.org/0000-0003-4804-8559
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81860424
Corresponding Author Hui Wang, PhD, Doctor, Department of Gastroenterology, The Affiliated Yan’an Hospital of Kunming Medical University, Renmin East Road, Panlong District, Kunming 650051, Yunnan Province, China. wanghui@kmmu.edu.cn
Key Words Acute pancreatitis; tRNA-derived fragments; tRNA-derived fragments 36; Mouse models; Ferroptosis; Reverse transcription quantitative polymerase chain reaction
Core Tip Based on reverse transcription quantitative polymerase chain reaction and bioinformatic analysis of small RNA sequencing data extracted from three patients and three healthy controls, and validated by 20 acute pancreatitis (AP) patients and 20 healthy controls, we found that tRNA-derived fragments 36 (tRF36) was significantly upregulated in AP. Furthermore, the results of the cell model of the MCP-83 cell line and knockdown of tRF36 suggested that tRF36 contributed to AP progression by promoting cell death.
Publish Date 2023-08-10 13:26
Citation Fan XR, Huang Y, Su Y, Chen SJ, Zhang YL, Huang WK, Wang H. Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments. World J Gastroenterol 2023; 29(30): 4642-4656
URL https://www.wjgnet.com/1007-9327/full/v29/i30/4642.htm
DOI https://dx.doi.org/10.3748/wjg.v29.i30.4642
Full Article (PDF) WJG-29-4642-with-cover.pdf
Full Article (Word) WJG-29-4642.docx
Manuscript File 83782_Auto_Edited-JLW.docx
Answering Reviewers 83782-Answering reviewers.pdf
Audio Core Tip 83782-Audio core tip.mp3
Biostatistics Review Certificate 83782-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 83782-Conflict-of-interest statement.pdf
Copyright License Agreement 83782-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 83782-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 83782-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 83782-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 83782-Language certificate.pdf
Supplementary Material 83782-Supplementary material.pdf
Peer-review Report 83782-Peer-review(s).pdf
Scientific Misconduct Check 83782-Bing-Wang JJ-2.png
Scientific Editor Work List 83782-Scientific editor work list.pdf