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Articles Published Processes
6/28/2023 10:03:21 AM | Browse: 108 | Download: 238
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Received |
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2023-04-03 05:06 |
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Peer-Review Started |
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2023-04-03 05:08 |
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To Make the First Decision |
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Return for Revision |
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2023-05-04 22:14 |
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Revised |
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2023-05-13 04:27 |
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Second Decision |
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2023-06-02 03:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-06-02 09:03 |
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Articles in Press |
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2023-06-02 09:03 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-06-15 08:50 |
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Publish the Manuscript Online |
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2023-06-28 10:03 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yun Jin, Ying-Hao Guo, Jia-Cheng Li, Qi Li, Dan Ye, Xiao-Xiao Zhang and Jiang-Tao Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Zhejiang Province |
LQ21H030005 |
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| Corresponding Author |
Jiang-Tao Li, FACS, MD, Chief Doctor, Professor, Department of Hepatopancreatobiliary Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou 310009, Zhejiang Province, China. zrljt@zju.edu.cn |
| Key Words |
Liver regeneration; Vascular endothelial growth factor; Nano materials; Liver resection |
| Core Tip |
Low regenerative ability of the liver remaining after partial hepatectomy may lead to serious complications including liver failure. The proliferation of liver sinusoidal endothelial cells (LSECs) is slower and occurs later compared to that of hepatocytes, leading to a delayed recovery of the hepatic sinusoids and impaired liver regeneration. Hepatocytes secrete vascular endothelial growth factor (VEGF) that promotes the proliferation of LSECs, and supplementation of exogenous VEGF after hepatectomy also increases the number of LSECs in the remaining liver, thus promoting the reestablishment of the hepatic sinusoids and accelerating liver regeneration. This review summarized the most recent findings on liver regeneration and new strategies for the localized delivery in the liver. |
| Publish Date |
2023-06-28 10:03 |
| Citation |
Jin Y, Guo YH, Li JC, Li Q, Ye D, Zhang XX, Li JT. Vascular endothelial growth factor protein and gene delivery by novel nanomaterials for promoting liver regeneration after partial hepatectomy. World J Gastroenterol 2023; 29(24): 3748-3757 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i24/3748.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i24.3748 |
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