BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
12/14/2023 5:08:46 AM | Browse: 77 | Download: 236
 |
Received |
|
2023-09-05 08:34 |
|
Peer-Review Started |
|
2023-09-05 08:34 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2023-09-15 22:51 |
|
Revised |
|
2023-10-09 03:34 |
|
Second Decision |
|
2023-11-01 07:44 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Company Editor-in-Chief |
|
2023-11-08 21:40 |
|
Articles in Press |
|
2023-11-08 21:40 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2023-12-06 14:55 |
|
Publish the Manuscript Online |
|
2023-12-14 05:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu-Sheng Zhang, Hong-Cai Zhou, Peng Wei, Long Chen, Wei-Hu Ma, Lin Ding, Shi-Cai Liang and Ben-Dong Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| First-Class Discipline Construction Founded Project of Ningxia Medical University and the School of Clinical Medicine |
2020008 |
|
| Corresponding Author |
Ben-Dong Chen, MD, Doctor, Department of Hepatobiliary Surgery, The General Hospital of Ningxia Medical University, No. 804 Shengli Street, Yinchuan 750004, Ningxia Hui Autonomous Region, China. bendong8511@nyfy.com.cn |
| Key Words |
Hepatocellular carcinoma; T cell immunoglobulin and mucin domain-containing protein 3; Programmed cell death protein 1; CD4+ T cells; CD8+ T cells |
| Core Tip |
This study investigated the effects of combined blockade of T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) and programmed cell death protein 1 (PD-1) on tumor development in a hepatocellular carcinoma (HCC) mouse model. We showed that combined TIM-3 and PD-1 blockade had more substantial inhibitory effects on tumor growth in mice compared with individual blockade. The combined therapy increased T cell infiltration and ameliorated CD4+ and CD8+ T cell exhaustion in HCC mouse model. Our findings proposed an effective immunotherapy and may provide more treatment options for HCC patients. |
| Publish Date |
2023-12-14 05:08 |
| Citation |
Zhang XS, Zhou HC, Wei P, Chen L, Ma WH, Ding L, Liang SC, Chen BD. Combined TIM-3 and PD-1 blockade restrains hepatocellular carcinoma development by facilitating CD4+ and CD8+ T cell-mediated antitumor immune responses. World J Gastrointest Oncol 2023; 15(12): 2138-2149 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i12/2138.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i12.2138 |
© 2004-2024 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
