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Articles Published Processes
12/14/2023 5:08:46 AM | Browse: 77 | Download: 194
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Received |
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2023-07-28 01:38 |
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Peer-Review Started |
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2023-07-28 01:40 |
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To Make the First Decision |
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Return for Revision |
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2023-09-26 20:35 |
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Revised |
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2023-10-16 12:01 |
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Second Decision |
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2023-11-13 00:56 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-11-17 09:02 |
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Articles in Press |
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2023-11-17 09:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-06 09:37 |
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Publish the Manuscript Online |
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2023-12-14 05:08 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wen-Jing Zhang, Ke-Lin Yue, Jing-Zhai Wang and Yu Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82260601 |
| Joint Foundation of Kunming Medical University and Yunnan Provincial Science and Technology Department |
202201AY070001-256 |
| Grant for Clinical Medical Center of Yunnan Provincial Health Commission |
2021LCZXXF-XH03 |
| Young Academic Talents Cultivation Foundation of Yunnan Province |
202205AC160070 |
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| Corresponding Author |
Yu Zhang, MD, PhD, Associate Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming 650032, Yunnan Province, China. yuzhang320@sina.com |
| Key Words |
Colorectal cancer; DNA methylation; Prognosis; Diagnosis; Bioinformatics; Heat shock factor protein 4 |
| Core Tip |
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract with clinical manifestations of diarrhea, constipation, and abdominal pain. We previously demonstrated that heat shock factor protein 4 (HSF4) accelerates the malignant biological behavior of CRC cells in vivo and in vitro. This study reveals that HSF4 is highly methylated and associated with HSF4 overexpression in CRC. Although the diagnostic and prognostic value of HSF4 methylation is poor, it may be involved in the process of CRC by mediating the expression of HSF4 or related genes. Combined with the finding of our previous study, the present study suggests that the high expression of HSF4 mRNA and protein and its oncogenic effects are likely to be associated with HSF4 methylation. |
| Publish Date |
2023-12-14 05:08 |
| Citation |
Zhang WJ, Yue KL, Wang JZ, Zhang Y. Association between heat shock factor protein 4 methylation and colorectal cancer risk and potential molecular mechanisms: A bioinformatics study. World J Gastrointest Oncol 2023; 15(12): 2150-2168 |
| URL |
https://www.wjgnet.com/1948-5204/full/v15/i12/2150.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v15.i12.2150 |
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