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Articles Published Processes
12/27/2023 5:42:53 AM | Browse: 67 | Download: 262
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Received |
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2023-09-22 13:20 |
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Peer-Review Started |
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2023-09-22 13:22 |
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To Make the First Decision |
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Return for Revision |
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2023-11-20 05:43 |
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Revised |
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2023-11-27 15:49 |
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Second Decision |
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2023-12-07 10:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-12-14 05:19 |
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Articles in Press |
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2023-12-14 05:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-12-22 05:27 |
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Publish the Manuscript Online |
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2023-12-27 05:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Fei Wang, Ruo-Yu He, Chan Xu, Xiao-Ling Li and Yan-Fei Cao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Zhejiang Province Traditional Chinese Medicine Science and Technology Program Project |
No. 2023ZF114 |
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| Corresponding Author |
Yan-Fei Cao, PhD, Doctor, Department of Gastroenterology, The Third Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, No. 23 Qingchun Rd, Shangcheng District, Hangzhou 310005, Zhejiang Province, China. zsyyxhky@126.com |
| Key Words |
Ulcerative colitis; Single-cell RNA sequencing; Phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
| Core Tip |
Ulcerative colitis (UC), a chronic inflammatory bowel disease linked to colorectal cancer, was investigated using single-cell RNA sequencing technology. The study unveiled sustained upregulation of inflammatory response pathways and characterized damaged endothelial cells during UC progression. Notably, the downregulation of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) exhibited a negative correlation with signal transducer and activator of transcription 3. LHPP's significant downregulation in UC patient tissues and plasma suggests its potential as a therapeutic target. The findings highlight LHPP as a key target in UC and emphasize its role in inflammation regulation, offering insights for potential therapeutic interventions. |
| Publish Date |
2023-12-27 05:42 |
| Citation |
Wang YF, He RY, Xu C, Li XL, Cao YF. Single-cell analysis identifies phospholysine phosphohistidine inorganic pyrophosphate phosphatase as a target in ulcerative colitis. World J Gastroenterol 2023; 29(48): 6222-6234 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i48/6222.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i48.6222 |
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