| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Public, Environmental & Occupational Health |
| Manuscript Type |
Observational Study |
| Article Title |
Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Yi-Jie Li, Brittney O Baumert, Nikos Stratakis, Jesse A Goodrich, Hao-Tian Wu, Jing-Xuan He, Yin-Qi Zhao, Max T Aung, Hong-Xu Wang, Sandrah P Eckel, Douglas I Walker, Damaskini Valvi, Michele A La Merrill, Justin R Ryder, Thomas H Inge, Stephanie Sisley, Rohit Kohli, Stavra A Xanthakos, Andrea A Baccarelli, Rob McConnell, David V Conti and Lida Chatzi |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Human Genome Research Institute and National Institute of Environmental Health |
U01HG013288 |
| National Institute of Environmental Health |
R01ES030364 |
| National Institute of Environmental Health |
R01ES029944 |
| Ministry of Science and Innovation and State Research Agency |
CEX2018-000806-S |
| United States Department of Agriculture |
6250-51000-053 |
| National Institutes of Health |
R01DK128117-01A1 |
| National Institute of Environmental Health |
T32-ES013678 |
| National Institute of Environmental Health |
R21ES029681 |
| National Institute of Environmental Health |
R01ES030691 |
| National Institute of Environmental Health |
U01HG013288 |
| National Institute of Environmental Health |
T32-ES013678 |
| National Institute of Environmental Health |
P30ES007048 |
| National Institute of Environmental Health |
U2CES030859 |
| National Institute of Environmental Health |
P30ES023515 |
| National Institute of Environmental Health |
P2CES033433 |
| California Environmental Protection Agency |
20-E0017 |
| National Cancer Institute and National Institute of Environmental Health |
P01CA196569 |
| European Union (“NextGenerationEU/PRTR”) |
IJC2020-043630-I |
| European Union’s Horizon Europe Research And Innovation Programme Under the Marie Skłodowska-Curie Actions Postdoctoral Fellowships |
101059245 |
| United States Department of Agriculture |
6250-51000-053 |
| National Institutes of Health |
R01DK128117−01A1 |
| The Teen-LABS Consortium: National Institute of Diabetes and Digestive and Kidney Diseases |
UM1DK072493 and UM1DK095710 |
|
| Corresponding Author |
Lida Chatzi, MD, PhD, Professor, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, No. 1845 N. Soto Street, Los Angeles, CA 90032, United States. chatzi@usc.edu |
| Key Words |
MicroRNA; Nonalcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver fibrosis; Lobular inflammation; Ballooning degeneration |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and its prevalence in adolescents is increasing. Studies suggest plasma microRNAs (miRNAs) are dysregulated in NAFLD, but relevant observational studies are scarce. In this study, we analyzed the expression of plasma miRNA in adolescents diagnosed with NAFLD by liver biopsy. We identified associations between histological features of NAFLD and plasma miRNA expression. Further, we found consistent expression of miRNA across different features of NAFLD. Although these results need further testing and validation, our findings suggest these miRNAs could be diagnostic and prognostic biomarkers of NAFLD. |
| Publish Date |
2024-01-26 07:56 |
| Citation |
Li YJ, Baumert BO, Stratakis N, Goodrich JA, Wu HT, He JX, Zhao YQ, Aung MT, Wang HX, Eckel SP, Walker DI, Valvi D, La Merrill MA, Ryder JR, Inge TH, Sisley S, Kohli R, Xanthakos SA, Baccarelli AA, McConnell R, Conti DV, Chatzi L. Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity. World J Gastroenterol 2024; 30(4): 332-345 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i4/332.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i4.332 |
