Publication Name	World Journal of Gastroenterology
Manuscript ID	88753
Country	China

Received	2023-10-08 02:48
Peer-Review Started	2023-10-08 02:50
To Make the First Decision
Return for Revision	2023-12-08 20:15
Revised	2023-12-15 15:10
Second Decision	2024-01-23 02:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-01-23 06:29
Articles in Press	2024-01-23 06:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-02-01 07:47
Publish the Manuscript Online	2024-02-26 13:28

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-on-chronic liver failure
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Zhang, Xiao-Ling Tian, Jie-Qun Li, Dong-Sheng Wu, Qiang Li and Bin Chen
ORCID	Author(s) ORCID Number Yu Zhang http://orcid.org/0000-0002-1692-6698 Dong-Sheng Wu http://orcid.org/0000-0001-7137-7954 Bin Chen http://orcid.org/0000-0002-5485-2263
Funding Agency and Grant Number	Funding Agency Grant Number the Domestic First-class Construction Disciplines of the Hunan University of Chinese Medicine Postgraduate Research Innovation Program of Hunan Province CX20220771 Clinical MedTech Innovation Project of Hunan Province 2021SK51415
Corresponding Author	Bin Chen, PhD, Chief Physician, Department of Hepatology, Institute of Hepatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, No. 95 Middle Shaoshan Road, Yuhua District, Changsha 410021, Hunan Province, China. chenbin0410@126.com
Key Words	Acute-on-chronic liver failure; Hypoxia-inducible factor-1α; Mitochondria; Metabolic phenotype; Immune cells
Core Tip	Our data were obtained from liver of patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF), whose mitochondrial function, metabolites, and immune microenvironment were less susceptible to any confounding factors caused by other failing organs. Widely infiltrating macrophages were originated from peripheral circulating monocytes in the liver of patients with HBV-ACLF. Mitochondrial oxidative phosphorylation was decreased, and anaerobic glycolysis was enhanced in patients with HBV-ACLF. Liver of patients made greater use of the extra-mitochondrial glycolytic pathway for providing energy. Bioenergetic alteration driven by hypoxia and mitochondrial dysfunction contribute to hepatic immune and metabolic remodeling, may leading to organ failure and poor clinical prognosis in patients with advanced HBV-ACLF.
Publish Date	2024-02-26 13:28
Citation	Zhang Y, Tian XL, Li JQ, Wu DS, Li Q, Chen B. Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with acute-on-chronic liver failure. World J Gastroenterol 2024; 30(8): 881-900
URL	https://www.wjgnet.com/1007-9327/full/v30/i8/881.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i8.881

Full Article (PDF)	WJG-30-881-with-cover.pdf
Full Article (Word)	WJG-30-881.docx
STROBE Statement	88753-STROBE statement.pdf
Manuscript File	88753_Auto_Edited-YJP.docx
Answering Reviewers	88753-Answering reviewers.pdf
Audio Core Tip	88753-Audio core tip.m4a
Biostatistics Review Certificate	88753-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88753-Conflict-of-interest statement.pdf
Copyright License Agreement	88753-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88753-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	88753-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	88753-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88753-Language certificate.pdf
Peer-review Report	88753-Peer-review(s).pdf
Scientific Misconduct Check	88753-Bing-Lin C-2.png
Scientific Editor Work List	88753-Scientific editor work list.pdf