Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	88815
Country	Taiwan

Received	2023-10-10 16:00
Peer-Review Started	2023-10-10 16:03
To Make the First Decision
Return for Revision	2023-12-07 09:19
Revised	2023-12-31 15:27
Second Decision	2024-02-01 02:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-02-01 06:27
Articles in Press	2024-02-01 06:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2024-01-30 17:56
Typeset the Manuscript	2024-03-04 06:15
Publish the Manuscript Online	2024-03-12 10:04

ISSN	1948-5204 (online)
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Category	Integrative & Complementary Medicine
Manuscript Type	Retrospective Cohort Study
Article Title	Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management
Manuscript Source	Unsolicited Manuscript
All Author List	Hsiang-Chun Lai, Ju-Chien Cheng, Hei-Tung Yip, Long-Bin Jeng and Sheng-Teng Huang
ORCID	Author(s) ORCID Number Hsiang-Chun Lai http://orcid.org/0000-0001-7885-619X Ju-Chien Cheng http://orcid.org/0000-0001-6238-313X Hei-Tung Yip http://orcid.org/0000-0003-4077-3473 Long-Bin Jeng http://orcid.org/0000-0002-2928-4698 Sheng-Teng Huang http://orcid.org/0000-0002-7495-6115
Funding Agency and Grant Number	Funding Agency Grant Number the National Science and Technology Council of Taiwan NSC112-2320-B-039-045- Department of Chinese Medicine and Pharmacy and Ministry of Health and Welfare MOHW-112-CMC-03 China Medical University Hospital DMR-111-013 China Medical University Hospital DMR-111-195 China Medical University Hospital DMR-112-004 China Medical University Hospital DMR-112-177
Corresponding Author	Sheng-Teng Huang, MD, PhD, Doctor, Professor, Department of Chinese Medicine, China Medical University Hospital; School of Chinese Medicine, China Medical University, No. 2 Yude Road, North District, Taichung 40447, Taiwan. sheng.teng@yahoo.com
Key Words	Hepatocellular carcinoma; Diabetes mellitus; Insulin; Herb; Taiwanese National health insurance research database
Core Tip	Type 2 diabetes mellitus (DM) is an independent risk factor for hepatocellular carcinoma (HCC), while insulin is a potent mitogen. In this propensity-score-matched population-based cohort study, we investigated whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin control. DM patients with regular herb use had a 12% decreased risk of HCC compared to the control group. The cohort with herb use of > 5 years cumulatively exhibited a protective effect against development of HCC. Moreover, among patients who developed HCC, herb users exhibited a longer survival time than non-users (adjusted hazard ratio = 0.78).
Publish Date	2024-03-12 10:04
Citation	Lai HC, Cheng JC, Yip HT, Jeng LB, Huang ST. Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management. World J Gastrointest Oncol 2024; 16(3): 716-731
URL	https://www.wjgnet.com/1948-5204/full/v16/i3/716.htm
DOI	https://dx.doi.org/10.4251/wjgo.v16.i3.716

Full Article (PDF)	WJGO-16-716-with-cover.pdf
Full Article (Word)	WJGO-16-716.docx
STROBE Statement	88815-STROBE statement.pdf
Manuscript File	88815_Auto_Edited-LiL-Kerr C-YJP.docx
Answering Reviewers	88815-Answering reviewers.pdf
Audio Core Tip	88815-Audio core tip.mp3
Biostatistics Review Certificate	88815-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	88815-Conflict-of-interest statement.pdf
Copyright License Agreement	88815-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	88815-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s)	88815-Informed consent statement.pdf
Institutional Review Board Approval Form or Document	88815-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	88815-Language certificate.pdf
Peer-review Report	88815-Peer-review(s).pdf
Scientific Misconduct Check	88815-Bing-Li L-2.png
Scientific Editor Work List	88815-Scientific editor work list.pdf