Publication Name	World Journal of Stem Cells
Manuscript ID	89703
Country	China

Received	2023-11-09 14:43
Peer-Review Started	2023-11-09 14:44
To Make the First Decision
Return for Revision	2023-12-17 01:33
Revised	2024-01-12 15:43
Second Decision	2024-02-18 01:43
Accepted by Journal Editor-in-Chief	2024-02-20 11:56
Accepted by Company Editor-in-Chief	2024-02-21 06:08
Articles in Press	2024-02-21 06:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-22 00:49
Publish the Manuscript Online	2024-04-25 05:24

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health
Manuscript Source	Unsolicited Manuscript
All Author List	Ling-Ling Wang, Zhan-Jin Lu, Shun-Kui Luo, Yun Li, Zhe Yang and Hong-Yun Lu
ORCID	Author(s) ORCID Number Ling-Ling Wang http://orcid.org/0000-0001-8066-7638 Shun-Kui Luo http://orcid.org/0000-0001-6252-1715 Hong-Yun Lu http://orcid.org/0000-0001-8794-0887
Funding Agency and Grant Number	Funding Agency Grant Number Basic and Applied Basic Research Foundation of Guangdong Province 2020A1515010123, 2021A1515010695 Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province 2019A030317011
Corresponding Author	Hong-Yun Lu, MD, PhD, Chief Doctor, Department of Endocrinology and Metabolism, Zhuhai People’s Hospital (Zhuhai Clinical Medical College of Jinan University, the First Hospital Affiliated with Medical College of Macao University of Science and Technology), No. 79 Kangning Road, Zhuhai 519000, Guangdong Province, China. luhongyun@jnu.edu.cn
Key Words	Hypoxia-inducible factor-2α; Bone marrow niche; Bone mesenchymal stem cells; Osteoporosis; Osteogenic/adipogenic differentiation; Mechanistic target of rapamycin signaling pathway
Core Tip	This manuscript explores the role of hypoxia-inducible factor 2alpha (HIF-2α) in bone mesenchymal stem cell (BMSC) osteogenic differentiation in the bone marrow niche, a role that is still unclear and controversial, via in vivo and in vitro experiments. We verified that downregulation of HIF-2α inhibits osteogenesis in vivo by generating mice with BMSC-specific HIF-2α knockout and applying interventions such as bilateral ovariectomy, semilethal irradiation, and treatment with dexamethasone. In vitro, we found that downregulation of HIF-2α can inhibit osteogenesis and increase adipogenesis by suppressing the mechanistic target of rapamycin signaling pathway, which may lead to the identification of drug target genes for the clinical treatment of osteoporosis.
Publish Date	2024-04-25 05:24
Citation	Wang LL, Lu ZJ, Luo SK, Li Y, Yang Z, Lu HY. Unveiling the role of hypoxia-inducible factor 2alpha in osteoporosis: Implications for bone health. World J Stem Cells 2024; 16(4): 389-409
URL	https://www.wjgnet.com/1948-0210/full/v16/i4/389.htm
DOI	https://dx.doi.org/10.4252/wjsc.v16.i4.389

Full Article (PDF)	WJSC-16-389-with-cover.pdf
The ARRIVE Guidelines	89703-The ARRIVE guidelines.pdf
Manuscript File	89703_Auto_Edited-YJP.docx
Answering Reviewers	89703-Answering reviewers.pdf
Audio Core Tip	89703-Audio core tip.mp3
Biostatistics Review Certificate	89703-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	89703-Conflict-of-interest statement.pdf
Copyright License Agreement	89703-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	89703-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	89703-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	89703-Language certificate.pdf
Peer-review Report	89703-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	89703-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	89703-Bing-Wang JJ-2.png
Scientific Editor Work List	89703-Scientific editor work list.pdf