Publication Name	World Journal of Gastroenterology
Manuscript ID	90756
Country	France

Received	2024-01-25 21:32
Peer-Review Started	2024-01-25 21:32
To Make the First Decision
Return for Revision	2024-02-01 21:53
Revised	2024-02-21 11:59
Second Decision	2024-03-28 06:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-03-28 08:48
Articles in Press	2024-03-28 08:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-21 08:54
Publish the Manuscript Online	2024-04-26 08:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Chitin-glucan improves important pathophysiological features of irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Caroline Valibouze, Caroline Dubuquoy, Philippe Chavatte, Michaël Genin, Veronique Maquet, Salvatore Modica, Pierre Desreumaux and Christel Rousseaux
ORCID	Author(s) ORCID Number Caroline Valibouze http://orcid.org/0000-0002-2198-1392 Caroline Dubuquoy http://orcid.org/0000-0003-1584-3601 Philippe Chavatte http://orcid.org/0000-0001-9620-7564 Michaël Genin http://orcid.org/0000-0002-9098-7528 Veronique Maquet http://orcid.org/0009-0009-3714-989X Salvatore Modica http://orcid.org/0009-0001-8386-0975 Pierre Desreumaux http://orcid.org/0000-0002-6127-5281 Christel Rousseaux http://orcid.org/0009-0003-3618-5895
Funding Agency and Grant Number	Funding Agency Grant Number Service Public de Wallonie (SPW-EER, convention 8588, Belgium)
Corresponding Author	Christel Rousseaux, PhD, Researcher, Intestinal Biotech Development, Faculté de Médicine, Pole Recherche Amphi JK, Bd du Pr Jules Leclercq, Lille 59045, France. crousseaux@ibd-biotech.com
Key Words	Chitin-glucan; Irritable bowel syndrome; Abdominal pain; Inflammation; Intestinal barrier; Molecular modelling; Microbial cell walls chelation
Core Tip	Currently available irritable bowel syndrome (IBS) treatments are often inadequate. Chitin-glucan is a novel, well-tolerated, non-digestible prebiotic considered a safe food ingredient by the European Food Safety Authority. This study suggests new capacities of chitin-glucan to target most pathophysiological mechanisms of IBS and its therapeutic potential as a promising new generation of prebiotics for patients with IBS or IBS-like symptoms.
Publish Date	2024-04-26 08:53
Citation	Valibouze C, Dubuquoy C, Chavatte P, Genin M, Maquet V, Modica S, Desreumaux P, Rousseaux C. Chitin-glucan improves important pathophysiological features of irritable bowel syndrome. World J Gastroenterol 2024; 30(16): 2258-2271
URL	https://www.wjgnet.com/1007-9327/full/v30/i16/2258.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i16.2258

Full Article (PDF)	WJG-30-2258-with-cover.pdf
The ARRIVE Guidelines	90756-The ARRIVE guidelines.pdf
Manuscript File	90756_Auto_Edited-YJP.docx
Answering Reviewers	90756-Answering reviewers.pdf
Audio Core Tip	90756-Audio core tip.mp3
Biostatistics Review Certificate	90756-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	90756-Conflict-of-interest statement.pdf
Copyright License Agreement	90756-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	90756-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	90756-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	90756-Language certificate.pdf
Peer-review Report	90756-Peer-review(s).pdf
Scientific Misconduct Check	90756-Bing-Chen YL-2.png
Scientific Editor Work List	90756-Scientific editor work list.pdf