| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Washed microbiota transplantation for Crohn’s disease: A metagenomic, metatranscriptomic, and metabolomic-based study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Ju Chen, Da-Ya Zhang, Xia Wu, Fa-Ming Zhang, Bo-Ta Cui, Yi-Hao Huang, Zu-Lun Zhang, Rui Wang and Fei-Hu Bai |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovation Platform for Academicians of Hainan Province |
No. YSPTZX202313 |
| Hainan Province Clinical Medical Center |
No. 2021818 |
| Hainan Provincial Health Industry Research Project |
No. 22A200078 |
| Hainan Provincial Postgraduate Innovation Research Project |
No. Qhyb2022-133 |
| Hainan Medical University Graduate Student Innovative Research Project |
No. HYYB2022A18 |
| Nanjing Medical University Fan Daiming Research Funds for Holistic Integrative Medicine |
No. 2020-3HIM |
|
| Corresponding Author |
Fei-Hu Bai, PhD, Chief Doctor, Professor, Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, No. 368 Yehai Avenue, Longhua District, Haikou 570216, Hainan Province, China. baifeihu_hy@163.com |
| Key Words |
Crohn’s disease; Clinical trials; Fecal microbiota transplant; Metagenome; Metatranscriptome; Metabolome |
| Core Tip |
Fecal microbiota transplantation (FMT) is a promising therapeutic approach for treating Crohn’s disease (CD). The new method of FMT, based on the automatic washing process, was named as washed microbiota transplantation (WMT). However, most existing studies have focused on observing clinical phenomena. In the present study, we found that the efficacy of WMT in CD may be due to the effective remodeling of the intestinal micro-ecological balance of patients through the combined in-depth analysis of metagenomic, metatranscriptomic, and metabolomic technologies. Multi-omics techniques can effectively help decipher the underlying mechanism of WMT for CD. |
| Publish Date |
2024-03-21 11:37 |
| Citation |
Chen SJ, Zhang DY, Wu X, Zhang FM, Cui BT, Huang YH, Zhang ZL, Wang R, Bai FH. Washed microbiota transplantation for Crohn’s disease: A metagenomic, metatranscriptomic, and metabolomic-based study. World J Gastroenterol 2024; 30(11): 1572-1587 |
| URL |
https://www.wjgnet.com/1007-9327/full/v30/i11/1572.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v30.i11.1572 |
