Publication Name	World Journal of Gastroenterology
Manuscript ID	92444
Country	China

Received	2024-01-26 02:04
Peer-Review Started	2024-01-26 02:04
To Make the First Decision
Return for Revision	2024-02-28 07:41
Revised	2024-03-05 06:54
Second Decision	2024-04-10 02:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2024-04-10 04:30
Articles in Press	2024-04-10 04:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-04-21 08:42
Publish the Manuscript Online	2024-04-26 08:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer
Manuscript Source	Invited Manuscript
All Author List	Xiao-Jun Zhang, Yan Yu, He-Ping Zhao, Lei Guo, Kun Dai and Jing Lv
ORCID	Author(s) ORCID Number Xiao-Jun Zhang http://orcid.org/0009-0003-2354-5353 Yan Yu http://orcid.org/0000-0003-1587-7748 He-Ping Zhao http://orcid.org/0000-0002-7896-6636 Lei Guo http://orcid.org/0000-0002-5166-5374 Kun Dai http://orcid.org/0000-0001-5091-7800 Jing Lv http://orcid.org/0000-0003-2801-743X
Funding Agency and Grant Number	Funding Agency Grant Number Xi’an Municipal Health Commission of China 2022qn07, 2023ms11
Corresponding Author	Jing Lv, MD, Doctor, Department of Clinical Laboratory, Honghui Hospital, Xi’an Jiaotong University, No. 555 Youyi Dong Road, Xi’an 710054, Shaanxi Province, China. lvjing-1219@163.com
Key Words	Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal adenocarcinoma; Tumor immune microenvironment; Immunosuppression; Immunotherapy
Core Tip	Esophageal cancer (EC) is a significant global health issue, and immunotherapy holds promise for treating this disease. However, resistance to immunotherapy may occur, and is usually associated with the tumor immune microenvironment (TIME). Understanding the TIME, especially the suppressive TIME, is crucial. The aim of this review is to elucidate the underlying mechanisms of the suppressive TIME in EC, including cell infiltration, immune cell subsets, cytokines and signaling pathways, as well as the downregulated expression of major histocompatibility complex molecules in tumor cells. This summary may help predict EC patient responses to immunotherapies and facilitate personalized treatments to optimize immunotherapeutic outcomes.
Publish Date	2024-04-26 08:53
Citation	Zhang XJ, Yu Y, Zhao HP, Guo L, Dai K, Lv J. Mechanisms of tumor immunosuppressive microenvironment formation in esophageal cancer. World J Gastroenterol 2024; 30(16): 2195-2208
URL	https://www.wjgnet.com/1007-9327/full/v30/i16/2195.htm
DOI	https://dx.doi.org/10.3748/wjg.v30.i16.2195

Full Article (PDF)	WJG-30-2195-with-cover.pdf
Manuscript File	92444_Auto_Edited-YJP.docx
Answering Reviewers	92444-Answering reviewers.pdf
Audio Core Tip	92444-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	92444-Conflict-of-interest statement.pdf
Copyright License Agreement	92444-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	92444-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	92444-Language certificate.pdf
Peer-review Report	92444-Peer-review(s).pdf
Scientific Misconduct Check	92444-Bing-Wang JJ-2.png
Scientific Editor Work List	92444-Scientific editor work list.pdf