Publication Name	World Journal of Methodology
Manuscript ID	9306
Country	Cyprus

Received	2014-01-30 10:07
Peer-Review Started	2014-01-30 16:54
To Make the First Decision	2014-03-12 16:59
Return for Revision	2014-03-19 11:44
Revised	2014-04-05 00:14
Second Decision	2014-06-27 17:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-06-27 17:51
Articles in Press	2014-06-27 18:11
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-07-16 03:48
Typeset the Manuscript	2014-09-30 16:20
Publish the Manuscript Online	2014-10-19 20:34

ISSN	2222-0682 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Pharmacology & Pharmacy
Manuscript Type	Review
Article Title	World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients
Manuscript Source	Invited Manuscript
All Author List	Christina N Kontoghiorghe, Nicholas Andreou, Katerina Constantinou and George J Kontoghiorghes
Funding Agency and Grant Number
Corresponding Author	George J Kontoghiorghes, PhD, Professor, Postgraduate Research Institute of Science, Technology, Environment and Medicine, 3 Ammochostou Street, Limassol 3021, Cyprus. kontoghiorghes.g.j@pri.ac.cy
Key Words	World health issues; Global diseases; Orphan drugs; Orphan diseases; Rare diseases; Orphan patients; Thalassaemia; Deferiprone; Deferasirox; Deferoxamine; Iron overload
Core Tip	The major world health problems are related to poverty and other monetary health issues, including the supply of orphan drugs for the treatment of rare and orphan diseases. Differences in disease profile, disease burden and monetary health policies influence the mortality and morbidity rates of patients in developed and developing countries. The inexpensive developmental procedure of the iron chelating drug, deferiprone, used in thalassaemia is proposed as a paradigm for orphan and rare drug development. Improvements in worldwide health policies including procedures for inexpensive drug development and alleviation of poverty could reduce the mortality and morbidity rates of patients worldwide.
Publish Date	2014-10-19 20:34
Citation	Kontoghiorghe CN, Andreou N, Constantinou K, Kontoghiorghes GJ. World health dilemmas: Orphan and rare diseases, orphan drugs and orphan patients. World J Methodol 2014; 4(3): 163-188
URL	http://www.wjgnet.com/2222-0682/full/v4/i3/163.htm
DOI	http://dx.doi.org/10.5662/wjm.v4.i3.163

Full Article (PDF)	WJM-4-163.pdf
Full Article (Word)	WJM-4-163.doc
Manuscript File	9306-Review.doc
Answering Reviewers	9306-Answering reviewers.pdf
Copyright License Agreement	9306-Copyright assignment.pdf
Peer-review Report	9306-Peer review(s).pdf
Scientific Misconduct Check	9306-CrossCheck.jpg
Scientific Editor Work List	9306-Scientific editor work list.pdf