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3/9/2015 3:58:00 PM | Browse: 1223 | Download: 1275
Publication Name World Journal of Gastroenterology
Manuscript ID 12802
Country/Territory China
Received
2014-07-26 13:29
Peer-Review Started
2014-07-26 16:21
To Make the First Decision
2014-08-15 12:19
Return for Revision
2014-08-21 17:53
Revised
2014-09-08 20:50
Second Decision
2014-11-25 18:01
Accepted by Journal Editor-in-Chief
2014-11-26 02:24
Accepted by Company Editor-in-Chief
2014-12-08 16:06
Articles in Press
2014-12-08 17:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-01-08 12:40
Typeset the Manuscript
2015-02-10 17:30
Publish the Manuscript Online
2015-03-09 15:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Virology
Manuscript Type Retrospective Study
Article Title Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients
Manuscript Source Unsolicited Manuscript
All Author List Dan-Hong Yang, Yuan-Jun Xie, Nian-Feng Zhao, Hong-Ying Pan, Ming-Wei Li and Hai-Jun Huang
Funding Agency and Grant Number
Corresponding Author Hong-Ying Pan, MD, Director, De¬partment of Infectious Diseases, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Hangzhou 310014, Zhejiang Province, China. panhy2014@163.com
Key Words Hepatitis B virus; Adefovir; Lamivudine; Tenofovir disoproxil fumarate; Viral resistance
Core Tip We retrospectively assessed the efficacy of switching to tenofovir disoproxil fumarate (TDF) monotherapy and continuous lamivudine (LAM) plus adefovir (ADV) combination therapy in LAM-resistant chronic hepatitis B (CHB) patients with suboptimal response to LAM plus ADV. Switching to TDF was effective and safe for LAM-resistant CHB patients and exerted stronger antiviral activity than continuous add-on therapy at week 48. Our findings suggest that suboptimal responders to LAM plus ADV should be switched as soon as possible to antiviral agents with higher potency, and TDF would be a viable option.
Publish Date 2015-03-09 15:58
Citation Yang DH, Xie YJ, Zhao NF, Pan HY, Li MW, Huang HJ. Tenofovir disoproxil fumarate is superior to lamivudine plus adefovir in lamivudine-resistant chronic hepatitis B patients. World J Gastroenterol 2015; 21(9): 2746-2753
URL http://www.wjgnet.com/1007-9327/full/v21/i9/2746.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i9.2746
Full Article (PDF) WJG-21-2746.pdf
Full Article (Word) WJG-21-2746.doc
Manuscript File 12802-Review.docx
Answering Reviewers 12802-Answering reviewers.pdf
Copyright License Agreement 12802-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 12802-Language certificate.pdf
Peer-review Report 12802-Peer review(s).pdf
Scientific Misconduct Check 12802-CrossCheck.jpg
Scientific Editor Work List 12802-Scientific editor work list.pdf