| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Autobiography |
| Article Title |
Negative association between trunk fat, insulin resistance and skeleton in obese women
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Emanuela A Greco, Davide Francomano, Rachele Fornari, Chiara Marocco, Carla Lubrano, Vincenza Papa, Francesca Wannenes, Luigi Di Luigi, Lorenzo M Donini, Andrea Lenzi, Antonio Aversa and Silvia Migliaccio |
| Funding Agency and Grant Number |
|
| Corresponding Author |
Silvia Migliaccio, MD, PhD, Endocrinology Unit, Department of Movement, Human and Health Sciences, University Foro Italico, Largo Lauro De Bosis 15, 00195 Rome, Italy. silvia.migliaccio@uniroma4.it |
| Key Words |
Obesity; Skeleton; Vitamin D; Osteocalcin; Insulin resistance; Trunk fat; Inflammation |
| Core Tip |
Recent studies have shown that high fat mass content might be a risk factor for osteoporosis and fragility fractures. We evaluated obese women for vitamin D, osteocalcin, inflammatory markers, metabolic and hormones profile, bone mineral density (BMD) and body composition by dual-energy X-ray absorptiometry. Our results show that in obese women trunk fat negatively correlates with BMD independently from vitamin D levels, likely as consequence of reduced insulin-like growth factor-1 and increased inflammatory markers. These data indicate that obesity cannot be considered a protective factor for osteoporosis and suggest that obese postmenopausal women should be investigated for possible alterations of skeletal metabolism. |
| Publish Date |
2013-04-15 20:21 |
| Citation |
Greco EA, Francomano D, Fornari R, Marocco C, Lubrano C, Papa V, Wannenes F, Di Luigi L, Donini LM, Lenzi A, Aversa A, Migliaccio S. Negative association between trunk fat, insulin resistance and skeleton in obese women. World J Diabetes 2013; 4(2): 31-39 |
| URL |
http://www.wjgnet.com/1948-9358/full/v4/i2/31.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v4.i2.31 |
