Publication Name	World Journal of Gastroenterology
Manuscript ID	1704
Country	China

Received	2012-12-28 09:42
Peer-Review Started	2012-12-29 16:13
To Make the First Decision	2013-03-04 13:58
Return for Revision	2013-03-06 21:24
Revised	2013-03-25 12:08
Second Decision	2013-04-27 10:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-04-28 00:09
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-05-10 17:16
Typeset the Manuscript	2013-05-23 16:00
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Research & Experimental Medicine
Manuscript Type	Autobiography
Article Title	Anticancer effects of sweet potato protein on human colorectal cancer cells
Manuscript Source	Invited Manuscript
All Author List	Peng-Gao Li, Tai-Hua Mu and Le Deng
Funding Agency and Grant Number	Funding Agency Grant Number Earmarked Fund for China Agriculture Research System CARS-11-B-19 “Technique of Processing and Utilization for Plant Proteins” from China-Argentina Science and Technology Cooperation Program 2010DFA32690 Grant from the Capital Medical University 2009ZR03 Capital Medical University 2012ZR17 Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions
Corresponding Author	Dr. Tai-Hua Mu, Key Laboratory of Agro-products Processing, Ministry of Agriculture, Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing 100193, China. mutaihuacaas@126.com
Key Words	Sweet potato protein; Colorectal cancer; Cell proliferation; Cell invasion; Metastasis
Core Tip	Sweet potato protein (SPP) is a type of serine protease inhibitor that suppresses the activity of trypsin. The current study showed that SPP significantly inhibited proliferation, migration and invasion of human colorectal cancer SW480 cells in vitro. Moreover, the protein significantly suppressed the growth of intraperitoneally xenografted human colorectal cancer HCT-8 cells and volume of bloody ascites formed in nude mice. Spontaneous lung metastasis of a murine lung carcinoma cell line was significantly inhibited by SPP in mice. Notably, both intragastric infusion and intraperitoneal injection of SPP were effective in animal models.
Publish Date	2013-06-04 12:34
Citation	Li PG, Mu TH, Deng L. Anticancer effects of sweet potato protein on human colorectal cancer cells. World J Gastroenterol 2013; 19(21): 3300-3308
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3300.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3300

Full Article (PDF)	WJG-19-3300.pdf
Manuscript File	1704-Review.doc
Answering Reviewers	1704-Answering Reviewers.doc
Copyright License Agreement	1704-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	1704-Language certificate.pdf
Peer-review Report	1704-Peer review(s).pdf
Scientific Editor Work List	1704-Scientific editor work list.doc