ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Topic Highlights |
Article Title |
Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
|
Manuscript Source |
Invited Manuscript |
All Author List |
Katsuhiko Nosho, Yasutaka Sukawa, Yasushi Adachi, Miki Ito, Kei Mitsuhashi, Hiroyoshi Kurihara, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Hisayoshi Igarashi, Reo Maruyama, Kohzoh Imai, Hiroyuki Yamamoto and Yasuhisa Shinomura |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Japanese Society of Gastroenterology Research Foundation |
to Nosho K |
Pancreas Research Foundation of Japan |
to Nosho K |
Medical Research Encouragement Prize of The Japan Medical Association |
to Nosho K |
The Japan Society for the Promotion of Science Challenging Exploratory Research |
25670371 (to Shinomura Y) |
Ono Cancer Research Foundation |
to Ito M |
|
Corresponding Author |
Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp |
Key Words |
BRAF; CpG island methylator phenotype; Colon neoplasia; Fusobacterium species; miR-21 |
Core Tip |
The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue. Our results showed that the frequency of F. nucleatum positivity in Japanese colorectal cancer was 8.6%, which was lower than that in United States cohort studies (13%). F. nucleatum positivity was significantly associated with microsatellite instability-high status. Additionally, F. nucleatum possesses immunosuppressive activities by inhibiting T-cell responses. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells, and molecular alterations for colorectal cancer prevention and treatment. |
Publish Date |
2016-01-06 16:13 |
Citation |
Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y. Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol 2016; 22(2): 557-566 |
URL |
http://www.wjgnet.com/1007-9327/full/v22/i2/557.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v22.i2.557 |