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1/6/2016 4:13:00 PM | Browse: 1163 | Download: 1147
Publication Name World Journal of Gastroenterology
Manuscript ID 21199
Country/Territory Japan
Received
2015-06-30 15:55
Peer-Review Started
2015-07-04 18:59
To Make the First Decision
2015-09-11 08:58
Return for Revision
2015-09-15 15:59
Revised
2015-09-25 01:56
Second Decision
2015-11-03 09:16
Accepted by Journal Editor-in-Chief
2015-11-03 14:15
Accepted by Company Editor-in-Chief
2015-11-13 16:04
Articles in Press
2015-11-13 16:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-17 13:16
Publish the Manuscript Online
2016-01-06 16:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Topic Highlights
Article Title Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer
Manuscript Source Invited Manuscript
All Author List Katsuhiko Nosho, Yasutaka Sukawa, Yasushi Adachi, Miki Ito, Kei Mitsuhashi, Hiroyoshi Kurihara, Shinichi Kanno, Itaru Yamamoto, Keisuke Ishigami, Hisayoshi Igarashi, Reo Maruyama, Kohzoh Imai, Hiroyuki Yamamoto and Yasuhisa Shinomura
Funding Agency and Grant Number
Funding Agency Grant Number
Japanese Society of Gastroenterology Research Foundation to Nosho K
Pancreas Research Foundation of Japan to Nosho K
Medical Research Encouragement Prize of The Japan Medical Association to Nosho K
The Japan Society for the Promotion of Science Challenging Exploratory Research 25670371 (to Shinomura Y)
Ono Cancer Research Foundation to Ito M
Corresponding Author Katsuhiko Nosho, MD, PhD, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. nosho@sapmed.ac.jp
Key Words BRAF; CpG island methylator phenotype; Colon neoplasia; Fusobacterium species; miR-21
Core Tip The human intestinal microbiome plays a major role in human health and diseases, including colorectal cancer. Metagenomic analyses have shown an enrichment of Fusobacterium nucleatum (F. nucleatum) in colorectal carcinoma tissue. Our results showed that the frequency of F. nucleatum positivity in Japanese colorectal cancer was 8.6%, which was lower than that in United States cohort studies (13%). F. nucleatum positivity was significantly associated with microsatellite instability-high status. Additionally, F. nucleatum possesses immunosuppressive activities by inhibiting T-cell responses. Thus, emerging evidence may provide insights for strategies to target microbiota, immune cells, and molecular alterations for colorectal cancer prevention and treatment.
Publish Date 2016-01-06 16:13
Citation Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H, Kanno S, Yamamoto I, Ishigami K, Igarashi H, Maruyama R, Imai K, Yamamoto H, Shinomura Y. Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J Gastroenterol 2016; 22(2): 557-566
URL http://www.wjgnet.com/1007-9327/full/v22/i2/557.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i2.557
Full Article (PDF) WJG-22-557.pdf
Full Article (Word) WJG-22-557.doc
Manuscript File 21199-Review.docx
Answering Reviewers 21199-Answering reviewers.pdf
Audio Core Tip 21199-Audio core tip.MP3
Conflict-of-Interest Disclosure Form 21199-Conflict-of-interest statement.pdf
Copyright License Agreement 21199-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21199-Language certificate.pdf
Peer-review Report 21199-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21199-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21199-Scientific misconduct check.pdf
Scientific Editor Work List 21199-Scientific editor work list.pdf