Publication Name	World Journal of Cardiology
Manuscript ID	2441
Country	Portugal

Received	2013-02-21 11:05
Peer-Review Started	2013-02-22 10:03
To Make the First Decision	2013-04-16 09:14
Return for Revision	2013-04-18 15:40
Revised	2013-04-23 21:41
Second Decision	2013-05-16 20:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-05-17 09:45
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-07 09:57
Publish the Manuscript Online	2013-06-28 16:48

ISSN	1949-8462 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Autobiography
Article Title	BLEED-Myocardial Infarction Score: Predicting mid-term post-discharge bleeding events
Manuscript Source	Invited Manuscript
All Author List	Sérgio Barra, Rui Providência, Francisca Caetano, Inês Almeida, Luís Paiva, Paulo Dinis and António Leitão Marques
Funding Agency and Grant Number
Corresponding Author	Dr. Sérgio Barra, Cardiology Department, Coimbra’s Hospital and University Centre-General Hospital, Quinta dos Vales, 3041-801 S. Martinho do Bispo, Coimbra, Portugal. sergioncbarra@gmail.com
Key Words	Myocardial infarction; Bleeding; Prediction model; Risk stratification
Core Tip	Prediction of mid- to long-term clinically significant bleeding following discharge for a myocardial infarction has received scarce attention from the scientific community. The BLEED-myocardial infarction (MI) prediction model is the first score designed to predict mid-term hemorrhagic risk in these patients. Easy to use and comprising clinical and analytical items that can be collected in a few minutes, BLEED-MI showed good calibration, accuracy and discriminative performance for predicting post-discharge hemorrhagic episodes and a composite endpoint of bleeding events plus all-cause mortality. Importantly, an accurate prediction of bleeding events was shown independently of mortality. Furthermore, a progressively increasing risk of the primary and secondary endpoints was seen with increasing BLEED-MI scores and our results suggested a very high capability of the BLEED-MI rule in identifying low-risk patients. Depending on its potential external validation in larger cohorts of patients, the BLEED-MI score may eventually help tailor therapeutic decisions
Publish Date	2013-06-28 16:48
Citation	Barra S, Providência R, Caetano F, Almeida I, Paiva L, Dinis P, Leit?o Marques A. BLEED-Myocardial Infarction Score: Predicting mid-term post-discharge bleeding events. World J Cardiol 2013; 5(6): 196-206
URL	http://www.wjgnet.com/1949-8462/full/v5/i6/196.htm
DOI	http://dx.doi.org/10.4330/wjc.v5.i6.196

Full Article (PDF)	WJC-5-196.pdf
Manuscript File	2441-Review.doc
Answering Reviewers	2441-Answering reviewers.doc
Copyright License Agreement	2441-Copyright assignment.doc
Peer-review Report	2441-Peer review(s).docx
Scientific Editor Work List	2441-Scientific editor work list.doc