Publication Name	World Journal of Gastroenterology
Manuscript ID	279
Country	China

Received	2012-08-23 09:53
Peer-Review Started	2012-08-23 13:33
To Make the First Decision
Return for Revision
Revised	2012-11-18 13:14
Second Decision	2013-02-08 09:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-02-08 11:20
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-03-13 10:12
Typeset the Manuscript	2013-04-20 13:27
Publish the Manuscript Online	2013-05-07 10:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis
Manuscript Source	Invited Manuscript
All Author List	Lian-Zhen Yu, Hai-Yang Wang, Shu-Ping Yang, Zhi-Ping Yuan, Fang-Yuan Xu, Chao Sun and Rui-Hua Shi
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81072692 Natural Science Foundation of Jiangsu Higher Education Institutions of China 10KJB320007
Corresponding Author	Rui-Hua Shi, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. ruihuashi@126.com
Key Words	Ulcerative colitis; Ulcerative colitis-related carcinogenesis; Interleukin-22; Interleukin-22R1; STAT3
Core Tip	This study investigates the expression of interleukin (IL)-22, IL-22R1, IL-23, and STAT3 in ulcerative colitis (UC) and UC-related carcinogenesis (UC-CRC) tissues from human and mouse. The results showed that IL-22 and related proteins were closely related to the severity of colitis, and the expression level of IL-22 and related proteins was higher in dysplasia tissues. IL-22/STAT3 signaling pathway was related to UC and UC-CRC. IL-22 can be used as a biomarker for determining the severity of UC and as an interesting therapeutic target in active UC and UC-CRC.
Publish Date	2013-05-07 10:53
Citation	Yu LZ, Wang HY, Yang SP, Yuan ZP, Xu FY, Sun C, Shi RH. Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis. World J Gastroenterol 2013; 19(17): 2638-2649
URL	http://www.wjgnet.com/1007-9327/full/v19/i17/2638.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i17.2638

Full Article (PDF)	WJG-19-2638.pdf
Manuscript File	279-Review.doc
Answering Reviewers	279-Answering reviewers.doc
Copyright License Agreement	279-Copyright assignment.doc
Institutional Review Board Approval Form or Document	ethic committee approval.docx
Non-Native Speakers of English Editing Certificate	279-Language certificate.pdf
Peer-review Report	279-Peer review(s).docx
Scientific Editor Work List	279-Scientific editor work list.doc