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Publication Name World Journal of Gastroenterology
Manuscript ID 3031
Country/Territory Japan
Received
2013-04-04 19:25
Peer-Review Started
2013-04-04 23:40
To Make the First Decision
2013-05-14 18:40
Return for Revision
2013-05-20 10:48
Revised
2013-06-12 19:03
Second Decision
2013-07-05 10:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-07-05 12:48
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-08-06 13:54
Publish the Manuscript Online
2013-08-24 14:11
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice
Manuscript Source Invited Manuscript
All Author List Kazuhiro Takahashi, Soichiro Murata, Kiyoshi Fukunaga and Nobuhiro Ohkohchi
Funding Agency and Grant Number
Funding Agency Grant Number
University of Tsukuba, the Basic Research Support Program for Young Researcher
Corresponding Author Dr. Nobuhiro Ohkohchi, MD, PhD, Department of Surgery, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba 3058575, Japan. nokochi3@md.tsukuba.ac.jp
Key Words Human platelet; Liver fibrosis; Hepatocyte apoptosis; Hepatocyte growth factor; Transforming growth factor-β; Matrix metallopeptidases
Core Tip We assessed the effects of human platelet transfusion on liver fibrosis. Severe combined immunodeficiency (SCID) mice were administered CCl4 and either phosphate-buffered saline or human platelets. The effects of a human platelet transfusion on liver fibrosis and hepatocyte apoptosis were compared. The fibrotic area, hydroxyproline content, and α-smooth muscle actin expression were decreased in mice that received human platelet transfusions. Transfusion increased mouse hepatocyte growth factor (HGF) and matrix metallopeptidases (MMP)-9 levels in the liver and decreased mouse transforming growth factor-β. Furthermore, transfusion suppressed hepatocyte apoptosis. Human platelets inhibited liver fibrosis in SCID mice. Increased concentration of HGF in the liver suppresses hepatic stellate cell activation, induces MMPs, and inhibits hepatocyte apoptosis.
Publish Date 2013-08-24 14:11
Citation Takahashi K, Murata S, Fukunaga K, Ohkohchi N. Human platelets inhibit liver fibrosis in severe combined immunodeficiency mice. World J Gastroenterol 2013; 19(32): 5250-5260
URL http://www.wjgnet.com/1007-9327/full/v19/i32/5250.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i32.5250
Full Article (PDF) WJG-19-5250.pdf
Manuscript File 3031-Review.doc
Answering Reviewers 3031-Answering reviewers.pdf
Copyright License Agreement 3031-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 3031-Language certificate.pdf
Peer-review Report 3031-Peer reviews.pdf
Scientific Editor Work List 3031-Scientific editor work list.doc