Category |
Gastroenterology & Hepatology |
Manuscript Type |
Topic Highlights |
Article Title |
Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?
|
Manuscript Source |
Invited Manuscript |
All Author List |
Satomi Koizumi, Terumi Kamisawa, Sawako Kuruma, Taku Tabata, Kazuro Chiba, Susumu Iwasaki, Yuka Endo, Go Kuwata, Koichi Koizumi, Tooru Shimosegawa, Kazuichi Okazaki and Tsutomu Chiba |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Health and Labour Sciences Research Grants for Research on Intractable diseases (Research on IgG4-related disease) from Ministry of Health, Labour and Welfare of Japan |
|
|
Corresponding Author |
Terumi Kamisawa, MD, PhD, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan. kamisawa@cick.jp
|
Key Words |
Immunoglobulin G4; Autoimmune pancreatitis; Gastritis; Colonic polyp; Ulcerative colitis |
Core Tip |
Although the concept of immunoglobulin G4 (IgG4)-related gastrointestinal disease remains unclear, there appear to be two types of IgG4-related gastrointestinal disease. One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach, consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells, which usually show submucosal spreading. The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach, colon, and major duodenal papilla, showing polypoid or mass-like lesions. It is of utmost importance to rule out malignancy. To avoid unnecessary resection, IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. |
Publish Date |
2013-09-21 09:08 |
Citation |
Koizumi S, Kamisawa T, Kuruma S, Tabata T, Chiba K, Iwasaki S, Endo Y, Kuwata G, Koizumi K, Shimosegawa T, Okazaki K, Chiba T. Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases? World J Gastroenterol 2013; 19(35): 5769-5774 |
URL |
http://www.wjgnet.com/1007-9327/full/v19/i35/5769.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v19.i35.5769 |