Publication Name	World Journal of Hepatology
Manuscript ID	4322
Country	United States

Received	2013-06-27 11:24
Peer-Review Started	2013-06-27 16:49
To Make the First Decision	2013-07-19 08:39
Return for Revision	2013-07-20 13:41
Revised	2013-07-30 23:10
Second Decision	2013-08-16 19:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-08-16 23:28
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-09-03 09:01
Publish the Manuscript Online	2013-10-01 17:51

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Minireviews
Article Title	Hepatitis C virus infection, microRNA and liver disease progression
Manuscript Source	Invited Manuscript
All Author List	Shubham Shrivastava, Anupam Mukherjee and Ratna B Ray
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health and SLU Liver Center Seed DK081817
Corresponding Author	Ratna B Ray, PhD, Department of Pathology, Saint Louis University, DRC 207, 1100 South Grand Boulevard, St. Louis, MO 63104, United States. rayrb@slu.edu
Key Words	Hepatitis C virus; MicroRNA; Liver disease; Interferon signaling; Circulatory microRNA
Core Tip	Hepatitis C virus (HCV) is the major cause of chronic liver disease that gradually progresses from chronic hepatitis to cirrhosis and hepatocellular carcinoma (HCC) during the course of infection. MicroRNAs (miRNAs) are small RNA molecules and have the ability to regulate gene expression by targeting mRNA degradation or translational repression. miRNAs regulate HCV life cycle either by supporting viral replication or by inhibiting interferon signaling pathway. Several miRNAs play important roles in HCV related inflammation, fibrosis and HCC development. This review focuses on the involvement of miRNA in HCV life cycle and virus mediated liver disease progression, emerging role of circulating miRNAs and exploitation of miRNA as alternative therapeutic approach for HCV infection.
Publish Date	2013-10-01 17:51
Citation	Shrivastava S, Mukherjee A, Ray RB. Hepatitis C virus infection, microRNA and liver disease progression. World J Hepatol 2013; 5(9): 479-486
URL	http://www.wjgnet.com/1948-5182/full/v5/i9/479.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i9.479

Full Article (PDF)	WJH-5-479.pdf
Manuscript File	4322-Review.docx
Answering Reviewers	4322-Answering reviewers.pdf
Copyright License Agreement	4322-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Table.docx
Peer-review Report	4322-Peer review(s).pdf
Scientific Editor Work List	4322-Scientific editor work list.doc