Publication Name	World Journal of Gastroenterology
Manuscript ID	4866
Country	United States

Received	2013-07-29 10:10
Peer-Review Started	2013-07-29 14:35
To Make the First Decision	2013-09-02 16:18
Return for Revision	2013-09-03 18:59
Revised	2013-09-12 20:21
Second Decision	2013-09-29 10:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-09-29 21:45
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-20 20:16
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review
Manuscript Source	Invited Manuscript
All Author List	Peter P Stanich, Robert Pilarski, Jonathan Rock, Wendy L Frankel, Samer El-Dika and Marty M Meyer
Funding Agency and Grant Number
Corresponding Author	Marty M Meyer, MD, Division of Gastroenterology, Hepatology and Nutrition, the Ohio State University Wexner Medical Center, 395 West 12th Avenue, Suite 200, Columbus, OH 43210, United States. marty.meyer@osumc.edu
Key Words	Adenoma; Bannayan-Riley-Ruvalcaba syndrome; Colon polyps; Colorectal cancer; Cowden syndrome; Endoscopy; Ganglioneuroma; Hamartoma; Hyperplastic; Phosphatase and tensin homolog on chromosome ten
Core Tip	Phosphatase and tensin homolog on chromosome ten (PTEN) hamartoma tumor syndrome has a high rate of colonic polyposis. In contrast with prior dogma, the majority of patients will have mixed polyp histologies including adenoma, hamartoma and hyperplastic. Thus, multiple polyp types should spur investigation for this syndrome with a thorough clinical exam and possibly genetic testing. There is likely an increased risk of colorectal cancer at a young age and surveillance colonoscopy is recommended. We recommend starting at age 35 years.
Publish Date	2014-03-12 11:24
Citation	Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM. Colonic manifestations of the PTEN hamartoma tumor syndrome: Case series and systematic review. World J Gastroenterol 2014; 20(7): 1833-1838
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1833.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1833

Full Article (PDF)	WJG-20-1833.pdf
Full Article (Word)	WJG-20-1833.doc
Manuscript File	4866-Review.doc
Answering Reviewers	4866-Answering Reviewers.pdf
Copyright License Agreement	4866-Coppyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130728221651.pdf
Peer-review Report	4866-Peer review(s).pdf
Scientific Editor Work List	4866-Scientific editor work list.doc