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Articles Published Processes
9/10/2014 8:55:00 PM | Browse: 1345 | Download: 934
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Received |
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2013-09-13 10:06 |
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Peer-Review Started |
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2013-09-13 14:47 |
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To Make the First Decision |
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2013-09-29 10:36 |
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Return for Revision |
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2013-09-29 13:55 |
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Revised |
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2013-10-01 02:08 |
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Second Decision |
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2013-10-19 14:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2013-10-20 08:33 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2013-12-03 11:28 |
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Publish the Manuscript Online |
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2013-12-19 19:04 |
Category |
Infectious Diseases |
Manuscript Type |
Meta-Analysis |
Article Title |
Preventing pediatric antibiotic-associated diarrhea and Clostridium difficile infections with probiotics: A meta-analysis
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Manuscript Source |
Invited Manuscript |
All Author List |
Lynne V McFarland and Shan Goh |
Funding Agency and Grant Number |
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Corresponding Author |
Lynne V McFarland, PhD, Department of Medicinal Chemistry, University of Washington, Metropolitan Park West, 1100 Olive Way #1400, Seattle, WA 98101, United States. lvmcfarl@u.washington.edu |
Key Words |
Probiotics; Pediatric; Antibiotic-associated diarrhea; Clostridium difficile; Saccharomyces boulardii; Lactobacillus rhamnosus; Safety; Meta-analysis; Randomized clinical trials |
Core Tip |
A meta-analysis was conducted (1985-2013) for clinical trials testing probiotics for the prevention of pediatric antibiotic-associated diarrhea (AAD) or Clostridium difficile infections (CDI). Overall, probiotics significantly reduced the incidence of pediatric AAD (pooled from 22 trials RR = 0.42, 95%CI: 0.33-0.53) and significantly reduced pediatric CDI (pooled from five trials RR = 0.35, 95%CI: 0.13-0.92). Of the two strains with multiple trials, both significantly reduced pediatric AAD: Saccharomyces boulardii lyo (RR = 0.43, 95%CI: 0.32-0.60) and Lactobacillus rhamnosus GG (RR = 0.36, 95%CI: 0.19-0.69). There was no significant effect by type of antibiotic, or by duration or dose of probiotic. |
Publish Date |
2013-12-19 19:04 |
Citation |
McFarland LV, Goh S. Preventing pediatric antibiotic-associated diarrhea and Clostridium difficile infections with probiotics: A meta-analysis. World J Meta-Anal 2013; 1(3): 102-120 |
URL |
http://www.wjgnet.com/2308-3840/full/v1/i3/102.htm |
DOI |
http://dx.doi.org/10.13105/wjma.v1.i3.102 |
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