Publication Name	World Journal of Gastroenterology
Manuscript ID	6691
Country	China

Received	2013-10-27 11:01
Peer-Review Started	2013-10-28 11:04
To Make the First Decision	2013-11-04 19:14
Return for Revision	2013-11-06 10:45
Revised	2013-11-19 18:20
Second Decision	2014-01-02 11:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-01-02 12:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-01-09 18:11
Typeset the Manuscript	2014-02-10 17:10
Publish the Manuscript Online	2014-03-06 14:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Li-Hua Ren, Wei-Xu Chen, Li-Juan Qian, Shuo Li, Min Gu and Rui-Hua Shi
Funding Agency and Grant Number	Funding Agency Grant Number Innovative Team Project to Shi RH CX11
Corresponding Author	Rui-Hua Shi, MD, PhD, Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. ruihuashi@126.com
Key Words	Gastroesophageal reflux diseases; Proton pump inhibitors; Prokinetics; GABA-B receptor agonists; Treatment; Meta-analysis
Core Tip	Proton pump inhibitors (PPIs) are generally accepted as the standard treatment of care for gastroesophageal reflux disease (GERD). However, many patients undergoing PPI treatment have no effective symptomatic relief. Although many studies have shown the clinical efficacy of adding prokinetics to PPI therapy in GERD, others have shown no therapeutic benefit. The efficacy and safety of combined prokinetic and PPI therapy for GERD remain controversial. In this retrospective meta-analysis, we find no advantage for the addition of prokinetics to a PPI therapeutic regimen, relative to PPI alone. However, combination therapy may improve symptom score and patient quality of life.
Publish Date	2014-03-06 14:13
Citation	Ren LH, Chen WX, Qian LJ, Li S, Gu M, Shi RH. Addition of prokinetics to PPI therapy in gastroesophageal reflux disease: A meta-analysis. World J Gastroenterol 2014; 20(9): 2412-2419
URL	http://www.wjgnet.com/1007-9327/full/v20/i9/2412.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i9.2412

Full Article (PDF)	WJG-20-2412.pdf
Full Article (Word)	WJG-20-2412.doc
Manuscript File	6691-Review.docx
Answering Reviewers	6691-Answering reviewers.pdf
Copyright License Agreement	6691-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	6691-Language certificate.pdf
Peer-review Report	6691-Peer review(s).pdf
Scientific Editor Work List	6691-Scientific editor work list.doc