Publication Name	World Journal of Gastroenterology
Manuscript ID	100069
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43
Manuscript Source	Unsolicited Manuscript
All Author List	Wei Yang, Rui Liu and Feng Xu
Funding Agency and Grant Number
Corresponding Author	Feng Xu, MD, Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Erqi District, Zhengzhou 450052, Henan Province, China. fengx2024@126.com
Key Words	Glial cell line-derived neurotrophic factor; Ulcerative colitis; Colonic motility; Connexin 43; Dextran sodium sulfate model
Core Tip	The study investigated the therapeutic potential of glial cell line-derived neurotrophic factor (GDNF) in ameliorating impaired colonic motility in a dextran sodium sulfate-induced ulcerative colitis mouse model. The findings revealed that GDNF partially enhanced colonic transit and alleviated intestinal inflammation, with its effects reliant on connexin 43 activity. The findings identified GDNF as a promising candidate for treating abnormal colonic motility in ulcerative colitis patients, highlighting the significance of connexin 43 in its therapeutic mechanism.
Citation	<p>Yang W, Liu R, Xu F. Glial cell line-derived neurotrophic factor improves impaired colonic motility in experimental colitis mice through connexin 43. <i>World J Gastroenterol</i> 2025; 31(8): 100069</p>

Received	2024-08-19 07:03
Peer-Review Started	2024-08-06 10:04
To Make the First Decision
Return for Revision	2024-11-23 19:22
Revised	2024-12-06 10:37
Second Decision	2024-12-25 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-12-25 06:39
Articles in Press	2024-12-25 06:39
Publication Fee Transferred	2024-12-16 02:17
Edit the Manuscript by Language Editor	2025-01-04 01:32
Typeset the Manuscript	2025-01-16 09:38

ISSN	1007-9327 (print) and 2219-2840 (online)
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