BPG is committed to discovery and dissemination of knowledge
Articles in Press
1/21/2025 3:01:19 AM | Browse: 20 | Download: 0
Publication Name World Journal of Gastroenterology
Manuscript ID 100221
Country Malaysia
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Perianal fistulizing Crohn’s disease: Mechanisms and treatment options focusing on cellular therapy
Manuscript Source Invited Manuscript
All Author List Payal Bhatnagar, Sherreen Elhariri, Ismail A S Burud and Nabil Eid
Funding Agency and Grant Number
Corresponding Author Nabil Eid, Assistant Professor, MD, PhD, Department of Anatomy, Division of Human Biology, School of Medicine, IMU University, No. 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Key Words Stem cell therapy; Crohn’s disease; Perianal fistulas; Regenerative medicine; Treatment outcomes; Extracellular vehicles; Autophagy; Magnetic resonance imaging
Core Tip Perianal fistulizing Crohn’s disease (PFCD) is a common complication of CD, characterized by complex pathogenic mechanisms involving inflammatory cell accumulation, particularly macrophages, and enhanced cytokine production. These processes drive epithelial-to-mesenchymal transition, myofibroblast activation, upregulation of matrix metalloproteinases, ultimately leading to fistula formation. While various medical and surgical options target inflammatory processes in this disease, recurrence remains a substantial challenge. Local administration of mesenchymal stem cells or their derived extracellular vehicles has emerged as a promising therapeutic strategy through suppression of the inflammatory cells and promotion of fistula healing in PFCD. Here we summarize the various mechanisms involved in PFCD pathogenesis, with particular emphasis on mesenchymal stem cell therapy and their derived extracellular vehicles.
Citation <p>Bhatnagar P, Elhariri S, Burud IAS, Eid N. Perianal fistulizing Crohn’s disease: Mechanisms and treatment options focusing on cellular therapy. <i>World J Gastroenterol</i> 2025; 31(9): 100221</p>
Received
2024-08-10 06:18
Peer-Review Started
2024-08-10 06:19
To Make the First Decision
Return for Revision
2024-12-29 02:55
Revised
2025-01-06 08:58
Second Decision
2025-01-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-01-21 03:01
Articles in Press
2025-01-21 03:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-02-06 02:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com