Publication Name	World Journal of Gastroenterology
Manuscript ID	101058
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Bing Wang, Yuan Li, Qin Ouyang, Meng-Ting Xu, Ying-Yu Wang, Sun-Jing Fu, Wei-Qi Liu, Xue-Ting Liu, Hao Ling, Xu Zhang, Rui-Juan Xiu and Ming-Ming Liu
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Natural Science Foundation No. 7212068 National Natural Science Foundation of China No. 81900747
Corresponding Author	Ming-Ming Liu, Associate Professor, PhD, Institute of Microcirculation, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 5 Dong Dan Third Alley, Dongcheng District, Beijing 100005, China. mingmingliu@imc.pumc.edu.cn
Key Words	Hepatic microcirculation; Biological oscillators; Mouse strains; Sex differences; Hepatic microhemodynamics
Core Tip	This study reveals significant strain and sex-dependent variations in hepatic microcirculation among murine, highlighting the implications for liver health. Male mice exhibited higher microvascular perfusion and erythrocyte concentration, while sex-specific differences in endothelial function were indicated across strains. Cluster of differentiation 31 expression linked to microvascular density varied by sex, suggesting a role in hepatic microhemodynamics. These findings suggest the necessity of integrating genetic and sex factors into the understanding of liver physiology and pathology, potentially guiding personalized therapeutic strategies.
Citation	<p>Wang B, Li Y, Ouyang Q, Xu MT, Wang YY, Fu SJ, Liu WQ, Liu XT, Ling H, Zhang X, Xiu RJ, Liu MM. Strain- and sex-dependent variability in hepatic microcirculation and liver function in mice. <i>World J Gastroenterol</i> 2025; 31(15): 101058</p>

Received	2024-09-04 01:19
Peer-Review Started	2024-09-04 01:19
To Make the First Decision
Return for Revision	2025-01-22 05:53
Revised	2025-02-02 03:55
Second Decision	2025-03-26 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-26 06:37
Articles in Press	2025-03-26 06:37
Publication Fee Transferred	2025-02-03 10:49
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-04-14 02:37

ISSN	1007-9327 (print) and 2219-2840 (online)
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