Publication Name	World Journal of Critical Care Medicine
Manuscript ID	101327
Country	United States

Category	Critical Care Medicine
Manuscript Type	Retrospective Study
Article Title	Impact of proning with and without inhaled pulmonary vasodilators and neuromuscular blocking agents in COVID acute respiratory distress syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Matthew Cabrera, Sarika Bharil, Meghan Chin, Seife Yohannes and Paul Clark
Funding Agency and Grant Number
Corresponding Author	Matthew Cabrera, MD, Department of Critical Care Medicine, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, United States. mpc125@georgetown.edu
Key Words	Acute respiratory distress syndrome; COVID; Prone position ventilation; Neuromuscular blocking agents; Pulmonary vasodilators; Mechanical ventilation; Plateau pressure; Driving pressure; Peak end expiratory pressure
Core Tip	In this retrospective study at two tertiary academic medical centers during the initial coronavirus disease 2019 surge, we examine trends in ventilator mechanics and outcomes of 114 acute respiratory distress syndrome (ARDS) patients receiving three adjunct therapies (prone positioning, neuromuscular blockade and inhaled vasodilations). We found a significant improvement in arterial oxygen partial pressure/fractional inspired oxygen ratio with the addition of inhaled vasodilators while proning and in lung compliance with the addition of continuous neuromuscular blockade amoung others. Our groups were not large enough to detect a difference in mortality or length of stay. However, this study provides a large amount of data and multi-day trends to further our understanding of the physiologic response to multiple adjunct therapies for ARDS in combination.
Citation	Cabrera M, Bharil S, Chin M, Yohannes S, Clark P. Impact of proning with and without inhaled pulmonary vasodilators and neuromuscular blocking agents in COVID acute respiratory distress syndrome. World J Crit Care Med 2025; In press

Received	2024-09-10 23:53
Peer-Review Started	2024-09-10 23:53
To Make the First Decision
Return for Revision	2025-01-20 06:22
Revised	2025-02-03 05:55
Second Decision	2025-02-25 02:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-25 07:53
Articles in Press	2025-02-25 07:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-05-15 06:54

ISSN	2220-3141(online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com