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Publication Name World Journal of Diabetes
Manuscript ID 101779
Country China
Category Endocrinology & Metabolism
Manuscript Type Retrospective Cohort Study
Article Title Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations
Manuscript Source Unsolicited Manuscript
All Author List Hui Liu, Ting Li, Xin-Lei Chen, Hong-Ling Yu and Ye-Rong Yu
Funding Agency and Grant Number
Corresponding Author Ye-Rong Yu, MD, Professor, Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, No. 37 Guoxue Alley, Wuhou District, Chengdu 610041, Sichuan Province, China. yerongyu@scu.edu.cn
Key Words Euglycemic clamp; Target glucose setting; Healthy subject; C-peptide; Pharmacodynamics; Endogenous insulin secretion
Core Tip Insulin therapy is of great importance in anti-diabetes treatment. This study focuses on the preclinical assessment of insulin preparation using the euglycemic clamp technique in healthy subjects. Typically, blood glucose is usually maintained below the individual’s baseline throughout the clamp to inhibit endogenous insulin secretion. The hypoglycemic risk would increase if the BG baseline is relatively lower. This retrospective cohort study enrolled euglycemic clamps evaluating the pharmacokinetics and pharmacodynamics of insulin aspart to explore optimal methodologies for conducting euglycemic clamps under these circumstances.
Citation <p>Liu H, Li T, Chen XL, Yu HL, Yu YR. Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations. <i>World J Diabetes</i> 2025; 16(2): 101779</p>
Received
2024-09-26 16:59
Peer-Review Started
2024-10-01 05:36
To Make the First Decision
Return for Revision
2024-11-06 08:39
Revised
2024-11-15 07:29
Second Decision
2024-11-26 11:31
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2024-12-05 07:16
Articles in Press
2024-12-05 07:16
Publication Fee Transferred
2024-11-18 05:29
Edit the Manuscript by Language Editor
2024-12-06 13:49
Typeset the Manuscript
2024-12-11 02:46
ISSN 1948-9358 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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