Publication Name	World Journal of Gastroenterology
Manuscript ID	102042
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Creeping fat and gut microbiota in Crohn’s disease
Manuscript Source	Invited Manuscript
All Author List	Ana EV Quaglio, Daniéla O Magro, Marcello Imbrizi, Ellen CS De Oliveira, Luiz C Di Stasi and Ligia Y Sassaki
Funding Agency and Grant Number	Funding Agency Grant Number Postdoctoral Scholarship Grant No. 5552/2024 PROPG/PROPE N°06/2024
Corresponding Author	Ligia Y Sassaki, MD, PhD, Professor, Department of Internal Medicine, Medical School, São Paulo State University, Av. Prof. Montenegro-Distrito de, Botucatu-SP, Botucatu 18618-686, São Paulo, Brazil. ligia.sassaki@unesp.br
Key Words	Creeping fat; Mesenteric adipose tissue; Gut microbiota; Crohn’s disease; Inflammatory bowel disease
Core Tip	Crohn’s disease is associated with creeping fat accumulation, influenced by factors such as gut microbiota. Dysbiosis, characterized by an increase in proteobacteria and species such as Clostridium innocuum, contributes to mesenteric fat accumulation and exacerbates inflammation. Modulating the microbiota through individualized interventions, such as environmental exposure modifications, fecal microbiota transplantation, and probiotics and prebiotics use, may be a potential strategy to reduce intestinal inflammation and mesenteric fat proliferation, improving therapeutic outcomes. However, further research is needed to elucidate the molecular mechanisms involved and develop biomarkers to identify patients who would benefit most from these approaches, considering their individual characteristics.
Citation	<p>Quaglio AE, Magro DO, Imbrizi M, De Oliveira EC, Di Stasi LC, Sassaki LY. Creeping fat and gut microbiota in Crohn’s disease. <i>World J Gastroenterol</i> 2025; 31(1): 102042</p>

Received	2024-10-07 20:03
Peer-Review Started	2024-10-07 20:03
To Make the First Decision
Return for Revision	2024-10-25 03:51
Revised	2024-11-01 23:04
Second Decision	2024-11-13 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2024-11-13 06:07
Articles in Press	2024-11-13 06:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2024-11-19 04:00

ISSN	1007-9327 (print) and 2219-2840 (online)
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