Publication Name	World Journal of Stem Cells
Manuscript ID	102088
Country	China

Category	Developmental Biology
Manuscript Type	Basic Study
Article Title	Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Fu, Yao-Ting Han, Jun-Ling Xie, Rong-Qi Liu, Bo Zhao, Xing-Liao Zhang, Jun Zhang and Jing Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Peak Disciplines (Type IV) of Institutions of Higher Learning in Shanghai and the China Postdoctoral Science Foundation 2022M722409
Corresponding Author	Jing Zhang, PhD, Professor, Research Center for Translational Medicine at East Hospital, School of Life Science, Tongji University, No. 1239 Siping Road, Shanghai 200092, China. 96755@tongji.edu.cn
Key Words	Mesenchymal stem cells; Exosome; Dermal papillary cells; Hair development; Liquid chromatography-mass spectrometry proteomic analysis
Core Tip	Liquid chromatography-mass spectrometry proteomic analysis was conducted to reveal the commonalities and heterogeneities across the human adipose-derived mesenchymal stem cell exosomes (hADSC-Exos) and human umbilical cord-derived mesenchymal stem cell exosomes. A total of 232 common proteins were found in hADSC-Exos and were categorized into 10 functional groups. We have confirmed that hADSC-Exos decrease glycogen synthase kinase-3β expression through the Wnt/β-catenin pathway, leading to increased proliferation and migration of dermal papillary cell. Excessive dihydrotestosterone can cause hair loss by shortening the hair growth phase, but hADSC-Exo treatment can reverse this effect. This study suggests that hADSC-Exo plays a role in hair regeneration through cell-to-cell communication via the Wnt/β-catenin pathway.
Citation	<p>Fu Y, Han YT, Xie JL, Liu RQ, Zhao B, Zhang XL, Zhang J, Zhang J. Mesenchymal stem cell exosomes enhance the development of hair follicle to ameliorate androgenetic alopecia. <i>World J Stem Cells</i> 2025; 17(3): 102088</p>

Received	2024-10-09 02:54
Peer-Review Started	2024-10-09 02:54
To Make the First Decision
Return for Revision	2025-01-09 02:41
Revised	2025-01-21 14:11
Second Decision	2025-02-21 08:24
Accepted by Journal Editor-in-Chief	2025-02-25 20:10
Accepted by Executive Editor-in-Chief	2025-02-26 08:11
Articles in Press	2025-02-26 08:11
Publication Fee Transferred	2025-01-24 11:24
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-13 09:07

ISSN	1948-0210 (online)
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