Publication Name	World Journal of Experimental Medicine
Manuscript ID	102175
Country	Uruguay

Category	Dentistry, Oral Surgery & Medicine
Manuscript Type	Retrospective Study
Article Title	Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Felipe Martins Silveira, Lauren Frenzel Schuch, Vanesa Pereira-Prado, Nelly Molina-Frechero, Sandra Lopez-Verdin, Marcelo Gómez Palacio-Gastélum, Miguel Arocena, Sven Niklander, Estefania Sicco and Ronell Bologna-Molina
Funding Agency and Grant Number
Corresponding Author	Ronell Bologna-Molina, PhD, Professor, Molecular Pathology Area, Department of Diagnosis in Pathology and Oral Medicine, University of the Republic, NA, Montevideo 11600, Uruguay. ronellbologna@hotmail.com
Key Words	Hypoxia-inducible factor-1α; Oral squamous cell carcinoma; Immunohistochemistry; Vimentin; E-cadherin
Core Tip	This study aimed to characterize the expression of Hypoxia-Inducible Factor 1-alpha (HIF-1α) at the invasive tumor front (ITF) in comparison to tumor islands in oral squamous cell carcinoma (OSCC) and to explore its relationship with E-cadherin and Vimentin expression. Based on the results of this study, HIF-1α appears to play a distinct role in OSCC tumor progression, underscoring the importance of exploring hypoxia-driven changes in cellular phenotype at the ITF of OSCC.
Citation	<p>Silveira FM, Schuch LF, Pereira-Prado V, Molina-Frechero N, Lopez-Verdin S, Gómez Palacio-Gastélum M, Arocena M, Niklander S, Sicco E, Bologna-Molina R. Hypoxia-inducible factor-1α at the invasive tumor front in oral squamous cell carcinoma. <i>World J Exp Med</i> 2025; 15(2): 102175</p>

Received	2024-10-11 01:22
Peer-Review Started	2024-10-29 00:45
To Make the First Decision
Return for Revision	2025-01-20 06:34
Revised	2025-02-02 02:21
Second Decision	2025-02-28 02:34
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-02-28 07:31
Articles in Press	2025-02-28 07:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-03-07 13:20

ISSN	2220-315x (online)
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