Publication Name	World Journal of Gastroenterology
Manuscript ID	102752
Country	Türkiye

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Arachidonate 15-lipoxygenase: A promising therapeutic target for alleviating inflammation in acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Duygu Kirkik and Sevgi Kalkanli Tas
Funding Agency and Grant Number
Corresponding Author	Duygu Kirkik, Assistant Professor, PhD, Department of Immunology, Hamidiye Medicine Faculty, University of Health Sciences, Mekteb-i Tıbbiyye-i Şâhane (Haydarpaşa) Külliyesi Selimiye Mah Tıbbiye Cad No. 38, Istanbul 34668, Türkiye. dygkirkik@gmail.com
Key Words	Acute pancreatitis; Arachidonate 15-lipoxygenase; Inflammation; Apoptosis; Autophagy
Core Tip	This editorial highlight the therapeutic potential of arachidonate 15-lipoxygenase (ALOX15) in acute pancreatitis (AP). By modulating inflammatory responses, promoting apoptosis, and facilitating autophagy, ALOX15 plays a critical role in cellular homeostasis and tissue recovery in AP. The enzyme’s dual action on pro- and anti-inflammatory pathways offers promising avenues for targeted therapies that go beyond symptomatic relief. Understanding ALOX15’s mechanisms could pave the way for innovative treatment approaches in AP, potentially reducing complications and improving patient outcomes.
Citation	<p>Kirkik D, Kalkanli Tas S. Arachidonate 15-lipoxygenase: A promising therapeutic target for alleviating inflammation in acute pancreatitis. <i>World J Gastroenterol</i> 2025; 31(15): 102752</p>

Received	2024-10-28 10:05
Peer-Review Started	2024-10-28 10:05
To Make the First Decision
Return for Revision	2025-02-14 00:02
Revised	2025-02-21 14:46
Second Decision	2025-03-07 03:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-03-07 06:38
Articles in Press	2025-03-07 06:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-03-17 23:17
Typeset the Manuscript	2025-04-14 02:46

ISSN	1007-9327 (print) and 2219-2840 (online)
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