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Publication Name World Journal of Experimental Medicine
Manuscript ID 102897
Country Japan
Category Oncology
Manuscript Type Basic Study
Article Title Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models
Manuscript Source Invited Manuscript
All Author List Anna Terasawa, Kazuhiro Shimazu, Hiroshi Nanjo, Masatomo Miura and Hiroyuki Shibata
Funding Agency and Grant Number
Funding Agency Grant Number
TAIHO Pharmaceutical AS2023A000122715
Nippon Kayaku NKCS20230416001
Corresponding Author Hiroyuki Shibata, MD, PhD, Professor, Department of Clinical Oncology, Akita University Graduate School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan. hiroyuki@med.akita-u.ac.jp
Key Words Malignant meningioma; Curcumin; Diarylpentanoid curcumin analog; Hepatocellular growth factor; Nuclear factor kappa B; N-cadherin
Core Tip Malignant meningiomas have a poor prognosis, but drug development is limited due to their rarity. The curcumin analog GO-Y030 showed approximately 10-16 times stronger inhibitory effects than curcumin on IOMM-Lee and HKBMM cell lines, in vitro. Intraperitoneal administration of GO-Y030 also significantly inhibited the growth of malignant meningiomas, IOMM-Lee inoculated in nude mouse models. GO-Y030 significantly inhibited hepatocyte growth factor, nuclear factor kappa B, and N-cadherin, which contribute to epithelial-mesenchymal transition.
Citation <p>Terasawa A, Shimazu K, Nanjo H, Miura M, Shibata H. Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models. <i>World J Exp Med</i> 2025; 15(2): 102897</p>
Received
2024-11-01 08:53
Peer-Review Started
2024-11-20 02:01
To Make the First Decision
Return for Revision
2024-12-17 05:39
Revised
2024-12-31 03:28
Second Decision
2025-01-21 02:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-01-21 09:25
Articles in Press
2025-01-21 09:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-02-27 01:54
ISSN 2220-315x (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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