Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	103194
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Natural surgical risks and age distribution in Chinese Peutz-Jeghers syndrome: Real-world research based on web surveys
Manuscript Source	Unsolicited Manuscript
All Author List	Nian-Jun Xiao, Su Liu, Zhe-Yi Han, Tong-Zhen Zhang, Zhi-Meng Jiang, Tao Sun, Jing Zhang, Lei Wang, Shou-Bin Ning and Wen Li
Funding Agency and Grant Number
Corresponding Author	Wen Li, Chief Physician, MD, PhD, Professor, Medical School of Chinese People’s Liberation Army (PLA), The First Medical Center, Chinese PLA General Hospital, NO.28 Fuxing Road, Haidian District, Beijing City, Beijing 100853, China. wen.li@ufh.com.cn
Key Words	Peutz-Jeghers syndrome; Web surveys; Intussusception; Balloon-assisted enteroscopy; Cumulative risk; Mucocutaneous pigmentation; Hamartomatous polyps
Core Tip	Peutz-Jeghers syndrome (PJS) is a rare disorder characterized by the presence of multiple intestinal polyps, which can lead to intussusception and often require surgery. Screening and preventive intervention for polyps in PJS may reduce the need for surgery. However, most guidelines regarding screening for polyps in PJS are based on expert opinion. This large sample survey demonstrated that patients with PJS exhibit markedly elevated natural surgical risks, particularly between the ages of 6 and 25 years. In light of these findings, we recommend that screening, surveillance, and preventive interventions if indicated, should commence at six years of age. We posit that our strategy based on natural surgical risk is more cost-effective and represents an optimal balance between preventing polyp-related complications and avoiding over-screening.
Citation	Xiao NJ, Liu S, Han ZY, Zhang TZ, Jiang ZM, Sun T, Zhang J, Wang L, Ning SB, Li W. Natural surgical risks and age distribution in Chinese Peutz-Jeghers syndrome: Real-world research based on web surveys. World J Gastrointest Surg 2025; In press

Received	2024-11-13 09:48
Peer-Review Started	2024-11-13 09:48
To Make the First Decision
Return for Revision	2025-03-03 12:06
Revised	2025-03-13 17:05
Second Decision	2025-04-15 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-15 07:05
Articles in Press	2025-04-15 07:05
Publication Fee Transferred	2025-03-18 12:27
Edit the Manuscript by Language Editor	2025-04-16 00:57
Typeset the Manuscript	2025-05-07 08:11

ISSN	1948-9366 (online)
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