Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	103198
Country	China

Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Prognostic value of preoperative fibrinogen, neutrophil-to-lymphocyte ratio, serum alpha-fetoprotein, and prealbumin for primary liver cancer undergoing trans-arterial chemoembolization
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Qi Liu, Ya-Dong Li, Jia-Xin Chen, Lin-Lin Zhang, Rong-Chun Guan, Wei Zhao and Ling-Yu Meng
Funding Agency and Grant Number	Funding Agency Grant Number Health Commission of Heilongjiang Province 0230404080031
Corresponding Author	Ling-Yu Meng, Clinical Laboratory, The Third Affiliated Hospital of Qiqihar Medical University, No. 3 Taishun Street, Tiefeng District, Qiqihar 161000, Heilongjiang Province, China. 18345202361@163.com
Key Words	Primary liver cancer; Trans-arterial arterial chemoembolization; Prognose; Fibrinogen and neutrophil-to-lymphocyte ratio score; Serum alpha-fetoprotein; Prealbumin
Core Tip	This study investigates the prognostic value of combining fibrinogen and neutrophil-to-lymphocyte ratio (F-NLR) score, alpha-fetoprotein (AFP), and prealbumin (PA) in patients with primary liver cancer undergoing transarterial chemoembolization. Our findings indicate that integrating F-NLR, which reflects systemic inflammation and coagulation status, AFP as a marker of tumor burden, and PA as an indicator of nutritional status and liver function, significantly enhances prognostic accuracy. This combined approach provides a basis for personalized treatment strategies, enabling precise identification of high-risk patients and optimizing therapeutic plans to improve outcomes.
Citation	Liu QQ, Li YD, Chen JX, Zhang LL, Guan RC, Zhao W, Meng LY. Prognostic value of preoperative fibrinogen, neutrophil-to-lymphocyte ratio, serum alpha-fetoprotein, and prealbumin for primary liver cancer undergoing trans-arterial chemoembolization. World J Gastrointest Oncol 2025; In press

Received	2025-02-18 08:28
Peer-Review Started	2025-02-18 08:28
To Make the First Decision
Return for Revision	2025-03-06 07:08
Revised	2025-03-21 09:17
Second Decision	2025-04-21 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-04-21 07:50
Articles in Press	2025-04-21 07:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-04-26 00:56
Typeset the Manuscript

ISSN	1948-5204 (online)
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